Page last updated: 2024-08-07 23:03:54
Bombesin receptor subtype-3
A bombesin receptor subtype-3 that is encoded in the genome of mouse. [OMA:O54798, PRO:DNx]
Synonyms
BRS-3
Research
Bioassay Publications (2)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (1)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| mk 5046 | Mus musculus (house mouse) | IC50 | 0.0054 | 1 | 1 |
| mk 5046 | Mus musculus (house mouse) | Ki | 0.0016 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| mk 5046 | Mus musculus (house mouse) | EC50 | 0.0210 | 2 | 2 |
Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach.Bioorganic & medicinal chemistry, , Jan-01, Volume: 23, Issue:1, 2015
Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.ACS medicinal chemistry letters, , Jan-13, Volume: 2, Issue:1, 2011