Page last updated: 2024-08-07 23:00:05

Stearoyl-CoA desaturase

A stearoyl-CoA desaturase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00767]

Synonyms

hSCD1;
EC 1.14.19.1;
Acyl-CoA desaturase;
Delta(9)-desaturase;
Delta-9 desaturase;
Fatty acid desaturase

Research

Bioassay Publications (4)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Compounds (3)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
mf 438Homo sapiens (human)IC500.021011
cay10566Homo sapiens (human)IC500.230033
mk 8245Homo sapiens (human)IC500.535544

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
stearoyl-CoA 9-desaturase activitymolecular functionCatalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. [RHEA:19721]
iron ion bindingmolecular functionBinding to an iron (Fe) ion. [GOC:ai]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
oxidoreductase activitymolecular functionCatalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators]
palmitoyl-CoA 9-desaturase activitymolecular functionCatalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O. [GOC:kmv, PMID:16443825]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
nucleoluscellular componentA small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Involved In

This protein is involved in 4 target(s):

TargetCategoryDefinition
unsaturated fatty acid biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782]
positive regulation of cold-induced thermogenesisbiological processAny process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]
monounsaturated fatty acid biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of monounsaturated fatty acid. [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825]
response to fatty acidbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. [GOC:lp]