Stearoyl-CoA desaturase

A stearoyl-CoA desaturase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00767]

hSCD1;
EC 1.14.19.1;
Acyl-CoA desaturase;
Delta(9)-desaturase;
Delta-9 desaturase;
Fatty acid desaturase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
mf 438	Homo sapiens (human)	IC50	0.0210	1	1
cay10566	Homo sapiens (human)	IC50	0.2300	3	3
mk 8245	Homo sapiens (human)	IC50	0.5355	4	4

This protein enables 5 target(s):

Target	Category	Definition
stearoyl-CoA 9-desaturase activity	molecular function	Catalysis of the reaction: 2 Fe(II)-[cytochrome b5] + 2 H+ + O2 + octadecanoyl-CoA = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O. [RHEA:19721]
iron ion binding	molecular function	Binding to an iron (Fe) ion. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
oxidoreductase activity	molecular function	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators]
palmitoyl-CoA 9-desaturase activity	molecular function	Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O. [GOC:kmv, PMID:16443825]

This protein is located in 4 target(s):

Target	Category	Definition
nucleolus	cellular component	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is active in 1 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

This protein is involved in 4 target(s):

Target	Category	Definition
unsaturated fatty acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms. [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782]
positive regulation of cold-induced thermogenesis	biological process	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]
monounsaturated fatty acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid. [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825]
response to fatty acid	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. [GOC:lp]