Pathways > vindoline and vinblastine biosynthesis
Page last updated: 2024-10-06
vindoline and vinblastine biosynthesis
Proteins (4)
| Protein | Synonyms | Taxonomy |
|---|
| Strictosidine beta-glucosidase | | Catharanthus roseus (Madagascar periwinkle) |
| Tabersonine 16-hydroxylase 1 | EC 1.14.14.103; Cytochrome P450 71D12 | Catharanthus roseus (Madagascar periwinkle) |
| Tabersonine 16-O-methyltransferase | EC 2.1.1.94 | Catharanthus roseus (Madagascar periwinkle) |
| Tabersonine 3-oxygenase | T3O; EC 1.14.14.50; 16-methoxytabersonine 3-oxygenase; Cytochrome P450 71D1; Cytochrome P450 71D1V2 | Catharanthus roseus (Madagascar periwinkle) |
Compounds (14)
| Compound | Description |
|---|
| hydronium ion | |
| Succinate | |
| iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| Glucose | A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. |
| vincristine | An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.) |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| alpha-Ketoglutarate | |
| secologanin | |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| Coenzyme A | |
| tabersonine | RN given refers to (5alpha,12beta,19alpha)-isomer; structure; can be viewed as indole fused to quinoline |
| Acetyl Coenzyme A | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |