Page last updated: 2024-10-06

vindoline, vindorosine and vinblastine biosynthesis

Proteins (2)

ProteinSynonymsTaxonomy
Tabersonine 16-hydroxylase 1EC 1.14.14.103; Cytochrome P450 71D12Catharanthus roseus (Madagascar periwinkle)
Tabersonine 16-O-methyltransferaseEC 2.1.1.94Catharanthus roseus (Madagascar periwinkle)

Compounds (20)

CompoundDescription
hydronium ion
Succinate
acetic acidProduct of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
vincristineAn antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
glucose, (beta-d)-isomer
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
strictosidineRN given refers to (2S-(2alpha,3beta,4beta(R*)))-isomer; formed by Mannich reaction of TRYPTAMINE with SECOLOGANIN; a precursor to ajmalicine and stemmadenine and other INDOLE ALKALOIDS
alpha-Ketoglutarate
catharanthineindole moiety of dimeric vinca alkaloids vinblastine & vincristine; RN given refers to (2alpha,5beta,6alpha,18beta)-isomer
secologanin
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
tabersonineRN given refers to (5alpha,12beta,19alpha)-isomer; structure; can be viewed as indole fused to quinoline
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.