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thyroid hormone biosynthesis

Proteins (5)

ProteinSynonymsTaxonomy
Cathepsin DEC 3.4.23.5Homo sapiens (human)
Procathepsin LEC 3.4.22.15; Cathepsin L1; Major excreted protein; MEP; p39 cysteine proteinaseMus musculus (house mouse)
Cathepsin BEC 3.4.22.1; Cathepsin B1Mus musculus (house mouse)
Cathepsin KEC 3.4.22.38Mus musculus (house mouse)
Thyroid peroxidaseTPO; EC 1.11.1.8Sus scrofa (pig)

Compounds (17)

CompoundDescription
hydronium ion
methimazoleA thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.
iodineA nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.
resorcinolRN given refers to parent cpd; structure in Merck Index, 9th ed, #7951
sulfathiazoleA sulfathiazole compound that is used as a short-acting anti-infective agent. It is no longer commonly used systemically due to its toxicity, but may still be applied topically in combination with other drugs for the treatment of vaginal and skin infections, and is still used in veterinary medicine.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
amitroleA non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.
hydrazoic acid
phloroglucinolA trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
4-aminobenzoic acidAn aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.
pepstatininhibits the aspartic protease endothiapepsin
hydrogen cyanideHydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.
thiouracilOccurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis.
thioureaA photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.
thiocyanateRN given refers to parent cpd