Pathways > tRNA modification in the nucleus and cytosol
Page last updated: 2024-10-06

tRNA modification in the nucleus and cytosol

Proteins (42)

ProteinSynonymsTaxonomy
tRNA (cytosine(38)-C(5))-methyltransferaseEC 2.1.1.204; DNA (cytosine-5)-methyltransferase-like protein 2; Dnmt2; DNA methyltransferase homolog HsaIIP; DNA MTase homolog HsaIIP; M.HsaIIP; PuMetHomo sapiens (human)
RNA cytosine C(5)-methyltransferase NSUN2EC 2.1.1.-; Myc-induced SUN domain-containing protein; Misu; NOL1/NOP2/Sun domain family member 2; Substrate of AIM1/Aurora kinase B; mRNA cytosine C(5)-methyltransferase; 2.1.1.-; tRNA cytosine C(5)-methyltransferase; 2.1.1.-; 2.1.1.203; tRNA methyltransHomo sapiens (human)
tRNA (cytosine(72)-C(5))-methyltransferase NSUN6EC 2.1.1.-; NOL1/NOP2/Sun and PUA domain-containing protein 1; NOL1/NOP2/Sun domain family member 6Homo sapiens (human)
Queuine tRNA-ribosyltransferase catalytic subunit 1EC 2.4.2.29; Guanine insertion enzyme; tRNA-guanine transglycosylaseHomo sapiens (human)
tRNA-dihydrouridine(20) synthase [NAD(P)+]-likeEC 1.3.1.91; Dihydrouridine synthase 2; Up-regulated in lung cancer protein 8; URLC8; tRNA-dihydrouridine synthase 2-like; hDUS2Homo sapiens (human)
EKC/KEOPS complex subunit TP53RKEC 3.6.-.-; Atypical serine/threonine protein kinase TP53RK; Nori-2; TP53-regulating kinase; 2.7.11.1; p53-related protein kinaseHomo sapiens (human)
Bifunctional glutamate/proline--tRNA ligaseBifunctional aminoacyl-tRNA synthetase; Cell proliferation-inducing gene 32 protein; Glutamatyl-prolyl-tRNA synthetaseHomo sapiens (human)
Multifunctional methyltransferase subunit TRM112-like proteintRNA methyltransferase 112 homologHomo sapiens (human)
tRNA dimethylallyltransferaseEC 2.5.1.75; Isopentenyl-diphosphate:tRNA isopentenyltransferase; IPP transferase; IPPT; hGRO1; tRNA isopentenyltransferase 1; IPTaseHomo sapiens (human)
Cytoplasmic tRNA 2-thiolation protein 1EC 2.7.7.-; ATP-binding domain-containing protein 3; Cancer-associated gene protein; Cytoplasmic tRNA adenylyltransferase 1Homo sapiens (human)
tRNA (guanine(26)-N(2))-dimethyltransferaseEC 2.1.1.216; tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferaseHomo sapiens (human)
tRNA pseudouridine(38/39) synthaseEC 5.4.99.45; tRNA pseudouridine synthase 3; tRNA pseudouridylate synthase 3; tRNA-uridine isomerase 3Homo sapiens (human)
tRNA wybutosine-synthesizing protein 5hTYW5; EC 1.14.11.42; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylaseHomo sapiens (human)
tRNA wybutosine-synthesizing protein 4tRNA yW-synthesizing protein 4; EC 2.1.1.290; EC 2.3.1.231; Leucine carboxyl methyltransferase 2; tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransfeHomo sapiens (human)
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4Protein Wuho homolog; hWH; WD repeat-containing protein 4Homo sapiens (human)
EKC/KEOPS complex subunit LAGE3L antigen family member 3; Protein ESO-3; Protein ITBA2Homo sapiens (human)
Cytoplasmic tRNA 2-thiolation protein 2Cytosolic thiouridylase subunit 2Homo sapiens (human)
tRNA (guanine(37)-N1)-methyltransferaseEC 2.1.1.228; M1G-methyltransferase; tRNA [GM37] methyltransferase; tRNA methyltransferase 5 homologHomo sapiens (human)
tRNA wybutosine-synthesizing protein 2 homologtRNA-yW-synthesizing protein 2; EC 2.5.1.114; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferaseHomo sapiens (human)
Threonylcarbamoyladenosine tRNA methylthiotransferaseEC 2.8.4.5; CDK5 regulatory subunit-associated protein 1-like 1; tRNA-t(6)A37 methylthiotransferaseHomo sapiens (human)
tRNA wybutosine-synthesizing protein 3 homologtRNA-yW-synthesizing protein 3; EC 2.1.1.282; tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferaseHomo sapiens (human)
Thyroid adenoma-associated proteinGene inducing thyroid adenomas proteinHomo sapiens (human)
tRNA (guanine(10)-N2)-methyltransferase homologEC 2.1.1.-; tRNA guanosine-2'-O-methyltransferase TRM11 homologHomo sapiens (human)
tRNA-specific adenosine deaminase 2EC 3.5.4.33; Deaminase domain-containing protein 1; tRNA-specific adenosine-34 deaminase subunit ADAT2Homo sapiens (human)
Probable tRNA (uracil-O(2)-)-methyltransferaseEC 2.1.1.211; Methyltransferase-like protein 19Homo sapiens (human)
tRNA methyltransferase 10 homolog AEC 2.1.1.221; RNA (guanine-9-)-methyltransferase domain-containing protein 2; tRNA (guanine(9)-N(1))-methyltransferase TRMT10AHomo sapiens (human)
Alkylated DNA repair protein alkB homolog 8Probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8; 2.1.1.229Homo sapiens (human)
Probable inactive tRNA-specific adenosine deaminase-like protein 3tRNA-specific adenosine-34 deaminase subunit ADAT3Homo sapiens (human)
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61AEC 2.1.1.220; mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; 2.1.1.-; tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRMT61AHomo sapiens (human)
Pseudouridylate synthase 7 homologEC 5.4.99.-Homo sapiens (human)
Ubiquitin-related modifier 1Homo sapiens (human)
tRNA-specific adenosine deaminase 1hADAT1; EC 3.5.4.34; tRNA-specific adenosine-37 deaminaseHomo sapiens (human)
Queuine tRNA-ribosyltransferase accessory subunit 2Queuine tRNA-ribosyltransferase domain-containing protein 1Homo sapiens (human)
Probable tRNA N6-adenosine threonylcarbamoyltransferaseEC 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; t(6)A synthase; O-sialoglycoprotein endopeptidase; hOSGEP; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP; tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPHomo sapiens (human)
tRNA:m(4)X modification enzyme TRM13 homologEC 2.1.1.225; Coiled-coil domain-containing protein 76Homo sapiens (human)
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1EC 4.1.3.44; Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; tRNA wybutosine-synthesizing protein 1 homolog; tRNA-yW-synthesizing proteinHomo sapiens (human)
Probable tRNA(His) guanylyltransferaseEC 2.7.7.79; Induced in high glucose-1; IHG-1; Interphase cytoplasmic foci protein 45; tRNA-histidine guanylyltransferaseHomo sapiens (human)
Probable tRNA methyltransferase 9BProbable tRNA methyltransferase 9-like protein; 2.1.1.-Homo sapiens (human)
tRNA (guanine-N(7)-)-methyltransferaseEC 2.1.1.33; Methyltransferase-like protein 1; mRNA (guanine-N(7)-)-methyltransferase; 2.1.1.-; miRNA (guanine-N(7)-)-methyltransferase; 2.1.1.-; tRNA (guanine(46)-N(7))-methyltransferase; tRNA(m7G46)-methyltransferaseHomo sapiens (human)
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferaseEC 2.1.1.205; 2'-O-ribose RNA methyltransferase TRM7 homolog; Protein ftsJ homolog 1Homo sapiens (human)
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6; tRNA(m1A58)-methyltransferase subunit TRM6; tRNA(m1A58)MTase subunit TRM6Homo sapiens (human)
EKC/KEOPS complex subunit TPRKBPRPK-binding protein; TP53RK-binding proteinHomo sapiens (human)

Compounds (19)

CompoundDescription
Succinate
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
guanine
queuinebase for nucleoside Q
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
alpha-Ketoglutarate
5'-methylthioadenosinestructure
5'-deoxyadenosinemain heading DEOXYADENOSINE refers to the 3' cpd
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
s-adenosylhomocysteine5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.
3,3-dimethylallyl pyrophosphateisomeric with isopentenyl pyrophosphate