Pathways > superpathway of ubiquinol-8 biosynthesis (prokaryotic)
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superpathway of ubiquinol-8 biosynthesis (prokaryotic)

Proteins (11)

ProteinSynonymsTaxonomy
Farnesyl diphosphate synthaseFPP synthase; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; GeranyltranstransferaseEscherichia coli K-12
Octaprenyl diphosphate synthaseEC 2.5.1.90; All-trans-octaprenyl-diphosphate synthase; Octaprenyl pyrophosphate synthase; OPP synthaseEscherichia coli K-12
Chorismate pyruvate-lyaseCL; CPL; EC 4.1.3.40Escherichia coli K-12
Isopentenyl-diphosphate Delta-isomeraseIPP isomerase; EC 5.3.3.2; IPP:DMAPP isomerase; Isopentenyl pyrophosphate isomeraseEscherichia coli K-12
3-octaprenyl-4-hydroxybenzoate carboxy-lyaseEC 4.1.1.98; Polyprenyl p-hydroxybenzoate decarboxylaseEscherichia coli K-12
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEEC 2.1.1.163; EC 2.1.1.201; 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase; Demethylmenaquinone methyltransferaseEscherichia coli K-12
4-hydroxybenzoate octaprenyltransferaseEC 2.5.1.39; 4-HB polyprenyltransferase; PHB octaprenyl transferaseEscherichia coli K-12
Ubiquinone biosynthesis O-methyltransferase2-octaprenyl-6-hydroxyphenol methylase; 2.1.1.222; 3-demethylubiquinone-8 3-O-methyltransferase; 2.1.1.64Escherichia coli K-12
2-octaprenyl-6-methoxyphenol hydroxylaseEC 1.14.13.-Escherichia coli K-12
2-octaprenylphenol hydroxylaseEC 1.14.13.240; 2-polyprenylphenol 6-hydroxylaseEscherichia coli K-12
3-demethoxyubiquinol 3-hydroxylaseEC 1.14.99.60; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylaseEscherichia coli K-12

Compounds (27)

CompoundDescription
diphosphoric acid
hydronium ion
ubiquinolreduced forms of ubiquinone; see also record for ubiquinol 10
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Polysorbate 80
methanolA colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Vanillic AcidA flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).
iodoacetamideAn alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonatea surfactant; structure given in first source
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
4-hydroxybenzaldehyde
4-hydroxybenzoic acid
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
isopentenyl pyrophosphatesubstrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
farnesyl pyrophosphatea sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation
geranyl diphosphatestructure in first source
dithiothreitolA reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
Edetic AcidA chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
2-octaprenyl phenolbiosynthetic precursor of ubiquinone-8
octoxynolNonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Octoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)