Page last updated: 2024-10-06

superpathway of tetracycline and oxytetracycline biosynthesis

Proteins (15)

ProteinSynonymsTaxonomy
Acetoacetyl-CoA reductase
Beta-ketoacyl synthase
Beta-ketoacyl synthase
OxyE
12-dehydrotetracycline 5-monooxygenase/anhydrotetracycline 6-monooxygenaseEC 1.14.13.234; EC 1.14.13.38
5a,11a-dehydrotetracycline/5a,11a-dehydrooxytetracycline reductaseEC 1.3.98.4; 12-dehydrotetracycline dehydrogenase; Dehydrooxytetracycline dehydrogenase; F420-dependent C5a-C11a reductase
Asparagine synthetase
O-methyltransferase family 2
OxyL-oxygenase
Cyclase/dehydrase
O-methyltransferase family protein
Hydroxylacyl-CoA dehydrogenase
Class I and II aminotransferase
OxyN-cyclase
Phosphopantetheine-binding protein

Compounds (16)

CompoundDescription
diphosphoric acid
hydronium ion
OxytetracyclineA TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES RIMOSUS and used in a wide variety of clinical conditions.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
Malonyl Coenzyme AA coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)