Page last updated: 2024-10-06

superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)

Proteins (10)

ProteinSynonymsTaxonomy
Homoserine O-acetyltransferaseEC 2.3.1.31; Homoserine O-trans-acetylaseSaccharomyces cerevisiae S288C
Cystathionine beta-synthaseEC 4.2.1.22; Beta-thionase; Serine sulfhydrase; Sulfur transfer protein 4Saccharomyces cerevisiae S288C
Cystathionine beta-lyaseCBL; EC 4.4.1.13; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; Sulfur transfer protein 3Saccharomyces cerevisiae S288C
Homocysteine/cysteine synthaseEC 2.5.1.47; EC 2.5.1.49; O-acetylserine/O-acetylhomoserine sulfhydrylase; OAS-OAH SHLase; OAS-OAH sulfhydrylaseSaccharomyces cerevisiae S288C
Sulfate adenylyltransferaseEC 2.7.7.4; ATP-sulfurylase; Methionine-requiring protein 3; Sulfate adenylate transferase; SATSaccharomyces cerevisiae S288C
Cystathionine gamma-lyaseEC 4.4.1.1; Gamma-cystathionase; Sulfur transfer protein 1Saccharomyces cerevisiae S288C
Cystathionine gamma-synthaseEC 2.5.1.48; O-succinylhomoserine (thiol)-lyase; Sulfur transfer protein 2Saccharomyces cerevisiae S288C
Phosphoadenosine phosphosulfate reductaseEC 1.8.4.8; 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAdoPS reductaseSaccharomyces cerevisiae S288C
Sulfite reductase [NADPH] flavoprotein componentEC 1.8.1.2Saccharomyces cerevisiae S288C
Adenylyl-sulfate kinaseEC 2.7.1.25; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenosine-5'-phosphosulfate kinase; APS kinaseSaccharomyces cerevisiae S288C

Compounds (27)

CompoundDescription
diphosphoric acid
hydronium ion
Succinate
Ammonium
hydrogen sulfideA flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
sirohemethe heme prosthetic group of the hemoprotein of E coli NADPH-sulfite reductase; reduces sulfite to sulfide or nitrite to ammonia; structure
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
sulfitesInorganic salts of sulfurous acid.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
2-ketobutyrate
carbamylhydrazineRN given refers to parent cpd
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
CysteineA thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
hydroxylamineA colorless inorganic compound (HONH2) used in organic synthesis and as a reducing agent, due to its ability to donate nitric oxide.
adenosine 3'-phosphate-5'-phosphate
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
Adenosine Phosphosulfate5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS.
phenylhydrazineRN given refers to parent cpd