Page last updated: 2024-10-06

superpathway of proto- and siroheme biosynthesis

Proteins (16)

ProteinSynonymsTaxonomy
Protoporphyrinogen oxidase 1, chloroplasticPPO1; EC 1.3.3.4Arabidopsis thaliana (thale cress)
Glutamyl-tRNA reductase 1, chloroplasticGluTR; EC 1.2.1.70Arabidopsis thaliana (thale cress)
Glutamyl-tRNA reductase 2, chloroplasticGluTR; EC 1.2.1.70Arabidopsis thaliana (thale cress)
Probable glutamyl-tRNA reductase 3, chloroplasticEC 1.2.1.70Arabidopsis thaliana (thale cress)
Probable delta-aminolevulinic acid dehydratase 2, chloroplasticALADH2; EC 4.2.1.24; Porphobilinogen synthaseArabidopsis thaliana (thale cress)
Porphobilinogen deaminase, chloroplasticPBG; EC 2.5.1.61; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase; Protein RUGOSA1Arabidopsis thaliana (thale cress)
Uroporphyrinogen-III synthase, chloroplasticAtUROS; EC 4.2.1.75; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthaseArabidopsis thaliana (thale cress)
Coproporphyrinogen-III oxidase 1, chloroplasticAtCPO-I; Coprogen oxidase; Coproporphyrinogenase; EC 1.3.3.3; Protein LESION INITIATION 2Arabidopsis thaliana (thale cress)
S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase, chloroplasticUrophorphyrin III methylase; EC 2.1.1.107; Urophorphyrin methylase 1; AtUPM1Arabidopsis thaliana (thale cress)
Uroporphyrinogen decarboxylase 2, chloroplasticUPD2; URO-D2; EC 4.1.1.37Arabidopsis thaliana (thale cress)
Uroporphyrinogen decarboxylase 1, chloroplasticUPD1; URO-D1; EC 4.1.1.37Arabidopsis thaliana (thale cress)
Ferrochelatase-2, chloroplasticAtFC2; EC 4.99.1.1; Ferrochelatase-II; AtFC-II; Heme synthase 2; Protoheme ferro-lyase 2Arabidopsis thaliana (thale cress)
Ferrochelatase-1, chloroplastic/mitochondrialAtFC1; EC 4.99.1.1; Ferrochelatase-I; AtFC-I; Heme synthase 1; Protoheme ferro-lyase 1Arabidopsis thaliana (thale cress)
Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplasticAtGSA1; GSA 1; EC 5.4.3.8; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1Arabidopsis thaliana (thale cress)
Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplasticGSA 2; EC 5.4.3.8; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2Arabidopsis thaliana (thale cress)
Protein At4g03205Arabidopsis thaliana (thale cress)

Compounds (30)

CompoundDescription
hydronium ion
SilverAn element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.
NADH
Ammonium
MercuryA silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
SodiumA member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
preuroporphyrinogen
sirohemethe heme prosthetic group of the hemoprotein of E coli NADPH-sulfite reductase; reduces sulfite to sulfide or nitrite to ammonia; structure
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
farnesyl pyrophosphatea sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation
CadmiumAn element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Porphobilinogen
hydroxylamineA colorless inorganic compound (HONH2) used in organic synthesis and as a reducing agent, due to its ability to donate nitric oxide.
protoporphyrinogen
coproporphyrinogen III
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
EthacridineA topically applied anti-infective agent.
sirohydrochlorinchromophore of desulfoviridin; structure
15,23-dihydrosirohydrochlorinstructure given in first source
hemeThe color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.