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superpathway of polyamine biosynthesis I

Proteins (7)

ProteinSynonymsTaxonomy
S-adenosylmethionine decarboxylase proenzymeAdoMetDC; SAMDC; EC 4.1.1.50Escherichia coli K-12
Inducible lysine decarboxylaseLDCI; EC 4.1.1.18Escherichia coli K-12
Constitutive lysine decarboxylaseLDCC; EC 4.1.1.18Escherichia coli K-12
AgmatinaseEC 3.5.3.11; Agmatine ureohydrolase; AUHEscherichia coli K-12
Biosynthetic arginine decarboxylaseADC; EC 4.1.1.19Escherichia coli K-12
Polyamine aminopropyltransferaseCadaverine aminopropyltransferase; 2.5.1.-; Putrescine aminopropyltransferase; PAPT; Spermidine aminopropyltransferase; 2.5.1.79; Spermidine synthase; SPDS; SPDSY; 2.5.1.16; Spermine synthase; 2.5.1.22; Thermospermine synthaseEscherichia coli K-12
Constitutive ornithine decarboxylaseEC 4.1.1.17Escherichia coli K-12

Compounds (28)

CompoundDescription
hydronium ion
AluminumA metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
ureaA compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
ArginineAn essential amino acid that is physiologically active in the L-form.
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
LithiumAn element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.
IronA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
monofluoromethylagmatinearginine decarboxylase inhibitor
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
CadaverineA foul-smelling diamine formed by bacterial decarboxylation of lysine.
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
5'-methylthioadenosinestructure
Edetic AcidA chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
SpermidineA polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
N-(3-aminopropyl)cadaverine
sapropterinRN given refers to parent cpd; co-factor required for catalytic activity of nitric oxide synthases
phenylhydrazineRN given refers to parent cpd
dicyclohexylammonium
ethylglyoxal bis(guanylhydrazone)RN given refers to parent cpd
2-fluoromethylornithinean ornithine decarboxylase antagonist