Page last updated: 2024-10-06

superpathway of pentose and pentitol degradation

Proteins (46)

ProteinSynonymsTaxonomy
Probable NAD(P)H-dependent D-xylose reductase xyl1XR; EC 1.1.1.307Aspergillus niger CBS 513.88
Glucose 1-dehydrogenaseGDH; GlcDH; EC 1.1.1.47; Aldose 1-dehydrogenase [NAD(P)(+)]; 1.1.1.359; Galactose 1-dehydrogenase; 1.1.1.120; 1.1.1.48Saccharolobus solfataricus
RibulokinaseEC 2.7.1.16Escherichia coli K-12
Xylulose kinaseXK; Xylulokinase; EC 2.7.1.17; 1-deoxy-D-xylulokinase; 2.7.1.-Escherichia coli K-12
D-xylulose reductaseEC 1.1.1.9; Xylitol dehydrogenase; XDHMorganella morganii
Ribitol 2-dehydrogenaseRDH; EC 1.1.1.56Klebsiella aerogenes
Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhHEC 4.1.2.28Escherichia coli K-12
Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagEKDG aldolase YagE; EC 4.1.2.51; Putative 2-dehydro-3-deoxy-D-pentonate aldolase YagE; 4.1.2.28Escherichia coli K-12
L-arabinitol 4-dehydrogenaseLAD; EC 1.1.1.12Aspergillus niger CBS 513.88
L-arabinitol 4-dehydrogenaseLAD; EC 1.1.1.12Trichoderma reesei
L-arabinose isomeraseEC 5.3.1.4Escherichia coli K-12
D-xylonate dehydrataseXAD; EC 4.2.1.82Haloferax volcanii DS2
D-xylonate dehydratase YjhGEC 4.2.1.82Escherichia coli K-12
D-xylonate dehydratase YagFEC 4.2.1.82Escherichia coli K-12
D-xylose 1-dehydrogenase [NADP(+)]XDH; EC 1.1.1.424Haloarcula marismortui ATCC 43049
L-xylulose reductaseEC 1.1.1.10Trichoderma reesei QM6a
Malate synthase AMSA; EC 2.3.3.9Escherichia coli K-12
Malate synthase GMSG; EC 2.3.3.9Escherichia coli K-12
Lactaldehyde dehydrogenaseEC 1.2.1.22; Aldehyde dehydrogenase A; Glycolaldehyde dehydrogenase; 1.2.1.21Escherichia coli K-12
Alpha-ketoglutarate semialdehyde dehydrogenaseKGSADH; EC 1.2.1.26Haloferax volcanii DS2
2,5-dioxopentanoate dehydrogenaseEC 1.2.1.26; Aldehyde dehydrogenase T; Alpha-ketoglutaric semialdehyde dehydrogenase AldhTSaccharolobus solfataricus P2
L-fucose isomeraseFucIase; EC 5.3.1.25; 6-deoxy-L-galactose isomerase; D-arabinose isomerase; 5.3.1.3Escherichia coli K-12
L-xylulose/3-keto-L-gulonate kinaseL-xylulokinase; EC 2.7.1.-; EC 2.7.1.53; 3-dehydro-L-gulonate kinaseEscherichia coli K-12
L-rhamnose isomeraseEC 5.3.1.14Escherichia coli K-12
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolaseEC 4.1.2.55Saccharolobus solfataricus
Arabinonate dehydrataseEC 4.2.1.5Saccharolobus solfataricus P2
2-dehydro-3-deoxy-D-arabinonate dehydrataseEC 4.2.1.141; 2-keto-3-deoxy-D-arabinonate dehydratase; KdaDSaccharolobus solfataricus P2
Xylose isomeraseEC 5.3.1.5; D-xylulose keto-isomeraseEscherichia coli K-12
L-ribulose-5-phosphate 4-epimerase AraDEC 5.1.3.4; Phosphoribulose isomeraseEscherichia coli K-12
L-fuculose phosphate aldolaseEC 4.1.2.17; D-ribulose-phosphate aldolase; L-fuculose-1-phosphate aldolaseEscherichia coli K-12
L-fuculokinaseEC 2.7.1.51; L-fuculose kinaseEscherichia coli K-12
L-ribulose-5-phosphate 4-epimerase SgbEEC 5.1.3.4; Phosphoribulose isomeraseEscherichia coli K-12
Probable 2-keto-3-deoxyxylonate dehydrataseKDXD; EC 4.2.1.141Haloferax volcanii DS2
Pentonolactonase XacCEC 3.1.1.15; EC 3.1.1.68; L-arabinonolactonase; Xylono-1,4-lactonaseHaloferax volcanii DS2
D-xylulose reductase AEC 1.1.1.9; Xylitol dehydrogenase AAspergillus oryzae RIB40
NAD(P)H-dependent D-xylose reductase xyl1XR; EC 1.1.1.-Trichoderma reesei
D-xylulose kinase AXylulokinase A; EC 2.7.1.17Aspergillus niger
Xylitol dehydrogenase Trichoderma reesei
Xylonate dehydratase xylDCaulobacter vibrioides NA1000
Fumarylacetoacetate hydrolase family protein Caulobacter vibrioides NA1000
Xylonolactonase xylCCaulobacter vibrioides NA1000
Alpha-ketoglutaric semialdehyde dehydrogenase xylACaulobacter vibrioides NA1000
Xylulokinase Morganella morganii
D-xylose reductase Aspergillus niger CBS 513.88
Alcohol dehydrogenase Saccharolobus solfataricus P2
D-xylose 1-dehydrogenase [NADP(+)] 1XDH 1; EC 1.1.1.424Haloferax volcanii DS2

Compounds (43)

CompoundDescription
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
xylose
ferrous sulfideRN given refers to cpd with MF of Fe-S; mackinawite & troilite both have MF Fe-S
NADH
MercuryA silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
potassium chlorideA white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
Sodium ChlorideA ubiquitous sodium salt that is commonly used to season food.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Adenylyl Imidodiphosphate5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial ATPase and also inhibits ATP-dependent reactions of oxidative phosphorylation.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
1,10-phenanthrolineRN given refers to parent cpd; inhibits Zn-dependent metalloproteinases
mercaptoethanolA water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
alpha-Ketoglutarate
L-arabino-1,4-lactone
CadmiumAn element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.
glyoxylate
dithiothreitolA reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
xyluloseA 5-carbon keto sugar.
xylulose-5-phosphateRN given refers to cpd with unspecified isomeric designation
glycolate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
2-keto-3-deoxy-D-xylonatestructure in first source
ribulose, (erythro-L)-isomer
xylitolA five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
glycolaldehydestructure
arabitolRN given refers to cpd without isomeric designation
galactitolA naturally occurring product of plants obtained following reduction of GALACTOSE. It appears as a white crystalline powder with a slight sweet taste. It may form in excess in the lens of the eye in GALACTOSEMIAS, a deficiency of GALACTOKINASE.
ribulose5-carbon keto sugar; minor descriptor (75-85); on-line & Index Medicus search PENTOSES (75-85); RN given refers to (erythro)-isomer
oxiconazoleRN given refers to parent cpd(Z)-isomer; structure given in first source
GlycerolA trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.
Coenzyme A
DitiocarbA chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.
EmetineThe principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.