Page last updated: 2024-10-06

superpathway of heme b biosynthesis from uroporphyrinogen-III

Proteins (5)

ProteinSynonymsTaxonomy
FerrochelataseEC 4.99.1.1; Heme synthase; Protoheme ferro-lyaseEscherichia coli K-12
Oxygen-dependent coproporphyrinogen-III oxidaseCPO; Coprogen oxidase; Coproporphyrinogenase; EC 1.3.3.3Escherichia coli K-12
Uroporphyrinogen decarboxylaseUPD; URO-D; EC 4.1.1.37Escherichia coli K-12
Oxygen-independent coproporphyrinogen III oxidaseCPO; EC 1.3.98.3; Coproporphyrinogen III dehydrogenase; CPDHEscherichia coli K-12
Protoporphyrinogen IX dehydrogenase [quinone]EC 1.3.5.3; Protoporphyrinogen IX dehydrogenase [menaquinone]; Protoporphyrinogen IX dehydrogenase [ubiquinone]; Protoporphyrinogen oxidase; PPOEscherichia coli K-12

Compounds (14)

CompoundDescription
hydronium ion
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
5'-deoxyadenosinemain heading DEOXYADENOSINE refers to the 3' cpd
protoporphyrinogen
coproporphyrinogen III
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
EthacridineA topically applied anti-infective agent.
hemeThe color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.