Page last updated: 2024-10-06

superpathway of fumitremorgin biosynthesis

Proteins (9)

ProteinSynonymsTaxonomy
Tryprostatin B synthaseEC 2.5.1.106; Brevianamide F prenyltransferase; Fumitremorgin biosynthesis protein BAspergillus fumigatus Af293
Nonribosomal peptide synthetase 13EC 6.3.3.-; Brevianamide F synthase; Fumitremorgin biosynthesis protein AAspergillus fumigatus
Verruculogen prenyltransferaseEC 2.5.1.107Aspergillus fischeri NRRL 181
Tryprostatin B 6-hydroxylaseEC 1.14.14.118; Fumitremorgin biosynthesis protein CAspergillus fumigatus
6-hydroxytryprostatin B O-methyltransferaseEC 2.1.1.293; Fumitremorgin biosynthesis protein DAspergillus fumigatus
Fumitremorgin C synthaseEC 1.14.19.71; Fumitremorgin biosynthesis protein EAspergillus fumigatus
12-alpha,13-alpha-dihydroxyfumitremorgin C prenyltransferaseEC 2.5.1.110; Fumitremorgin biosynthesis protein HAspergillus fumigatus
Verruculogen synthaseEC 1.14.11.38; Fumitremorgin biosynthesis protein FAspergillus fumigatus Af293
Fumitremorgin C monooxygenaseEC 1.14.14.119; Fumitremorgin biosynthesis protein GAspergillus fumigatus

Compounds (19)

CompoundDescription
diphosphoric acid
hydronium ion
Succinate
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
demethoxyfumitremorgin cisolated from the fermentation broth of Aspergillus fumigatus; a mammalian cell cycle inhibitor; structure given in first source
fumitremorgin bintermediary in TR-2 mycotoxin biosyn; RN given refers to (5aR-(5aalpha,6alpha,12beta,14aalpha))-isomer; structure given in first source
fumitremorgin aisolated from fungus Aspergillus fumigatus; structure given in first source; RN given refers to (5R-(5alpha,10alpha,10aalpha,14aalpha,15balpha))-isomer
verruculogencomplex 6-O-methylindole cpd containing 3 nitrogens; induces tremor; tremorigenic metabolite from Penicillium verruculosum isolated from moldy peanuts; decreases GABA levels in CNS; structure
alpha-Ketoglutarate
brevianamide fisolated from the endophyte from Aspergillus fumigatus associated with Melia azedarach L that could be used to develop a natural eco-friendly herbicide.structure in first source
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
tryprostatin bisolated from Aspergillus fumigatus; a mammalian cell cycle inhibitor; structure given in first source
tryprostatin aisolated from Aspergillus fumigatus; a mammalian cell cycle inhibitor; structure given in first source
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
tryptoquivalinetremor-producing metabolite from Aspergillus clavatus; tetrapeptide derived from tryptophan, anthranilic acid, valine, & methylalanine; structure & N1 names previously assigned to tryptoquivaline C & tryptoquivaline D found to be incorrect & are revised in third source; see also record for tryptoquivalone; structure in third source