Page last updated: 2024-10-06
superpathway of erythromycin biosynthesis
Proteins (18)
| Protein | Synonyms | Taxonomy |
|---|---|---|
| 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | DEBS 1; EC 2.3.1.94; 6-deoxyerythronolide B synthase I; Erythronolide synthase; ORF C | Saccharopolyspora erythraea |
| 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4 | DEBS 2; EC 2.3.1.94; 6-deoxyerythronolide B synthase II; Erythronolide synthase; ORF B | Saccharopolyspora erythraea |
| 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6 | DEBS 3; EC 2.3.1.94; 6-deoxyerythronolide B synthase III; Erythronolide synthase; ORF C | Saccharopolyspora erythraea |
| Erythromycin biosynthesis sensory transduction protein EryC1 | Saccharopolyspora erythraea NRRL 2338 | |
| 3-alpha-mycarosylerythronolide B desosaminyl transferase | EC 2.4.1.278; Desosaminyl transferase EryCIII; Erythromycin biosynthesis protein CIII | Saccharopolyspora erythraea NRRL 2338 |
| Erythromycin 3''-O-methyltransferase | EC 2.1.1.254; Erythromycin biosynthesis protein G | Saccharopolyspora erythraea NRRL 2338 |
| Erythromycin C-12 hydroxylase | EC 1.14.13.154; Cytochrome P450 113A1; CYP113A1; Erythromycin D C-12 hydroxylase | Saccharopolyspora erythraea NRRL 2338 |
| Glucose-1-phosphate thymidylyltransferase | Saccharopolyspora erythraea NRRL 2338 | |
| dTDP-glucose 4,6-dehydratase | Saccharopolyspora erythraea | |
| NDP-4-keto-6-deoxy-glucose 2,3-dehydratase | Saccharopolyspora erythraea NRRL 2338 | |
| TDP-desosamine-N-dimethyltransferase | Saccharopolyspora erythraea NRRL 2338 | |
| dTDP-4-keto-6-deoxy-L-hexose 4-reductase | Saccharopolyspora erythraea NRRL 2338 | |
| EryCV NDP-4,6-dideoxyhexose 3,4-enoyl reductase | Saccharopolyspora erythraea NRRL 2338 | |
| EryCIV NDP-6-deoxyhexose 3,4-dehydratase | Saccharopolyspora erythraea NRRL 2338 | |
| 6-DEB TDP-mycarosyl glycosyltransferase | Saccharopolyspora erythraea NRRL 2338 | |
| NDP-hexose 2,3-enoyl reductase | Saccharopolyspora erythraea NRRL 2338 | |
| EryBIII NDP-4-keto-2,6-dideoxyhexose 3-C-methyltransferase | Saccharopolyspora erythraea NRRL 2338 | |
| Cytochrome P450 family protein EryCII | Erythromycin biosynthesis protein CII | Saccharopolyspora erythraea NRRL 2338 |
Compounds (23)
| Compound | Description |
|---|---|
| diphosphoric acid | |
| hydronium ion | |
| Ammonium | |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| Erythromycin | A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| thymidine 5'-triphosphate | RN given refers to parent cpd |
| 6-deoxyerythronolide b | Streptomyces erythreus metabolite; presumed intermediate in biosynthesis of erythromycins; structure given in first source |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| alpha-Ketoglutarate | |
| 5'-deoxyadenosine | main heading DEOXYADENOSINE refers to the 3' cpd |
| glutamate | |
| glucose-1-phosphate | RN given refers to (alpha-D-Glc)-isomer |
| thymidine 5'-diphosphate | see also record for thymidine 3',5'-diphosphate, RN 2863-04-9 |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| Coenzyme A | |
| dTDP-4-amino-4,6-dideoxy-glucose | structure in first source |
| deoxythymidine diphosphate-glucose | structure given in first source |
| erythronolide b | intermediate of erythromycin biogenesis; structure in first source |
| propionyl-coenzyme A | RN given refers to parent cpd |