Page last updated: 2024-10-06

superpathway of erythromycin biosynthesis

Proteins (18)

ProteinSynonymsTaxonomy
6-deoxyerythronolide-B synthase EryA1, modules 1 and 2DEBS 1; EC 2.3.1.94; 6-deoxyerythronolide B synthase I; Erythronolide synthase; ORF CSaccharopolyspora erythraea
6-deoxyerythronolide-B synthase EryA2, modules 3 and 4DEBS 2; EC 2.3.1.94; 6-deoxyerythronolide B synthase II; Erythronolide synthase; ORF BSaccharopolyspora erythraea
6-deoxyerythronolide-B synthase EryA3, modules 5 and 6DEBS 3; EC 2.3.1.94; 6-deoxyerythronolide B synthase III; Erythronolide synthase; ORF CSaccharopolyspora erythraea
Erythromycin biosynthesis sensory transduction protein EryC1Saccharopolyspora erythraea NRRL 2338
3-alpha-mycarosylerythronolide B desosaminyl transferaseEC 2.4.1.278; Desosaminyl transferase EryCIII; Erythromycin biosynthesis protein CIIISaccharopolyspora erythraea NRRL 2338
Erythromycin 3''-O-methyltransferaseEC 2.1.1.254; Erythromycin biosynthesis protein GSaccharopolyspora erythraea NRRL 2338
Erythromycin C-12 hydroxylaseEC 1.14.13.154; Cytochrome P450 113A1; CYP113A1; Erythromycin D C-12 hydroxylaseSaccharopolyspora erythraea NRRL 2338
Glucose-1-phosphate thymidylyltransferase Saccharopolyspora erythraea NRRL 2338
dTDP-glucose 4,6-dehydratase Saccharopolyspora erythraea
NDP-4-keto-6-deoxy-glucose 2,3-dehydratase Saccharopolyspora erythraea NRRL 2338
TDP-desosamine-N-dimethyltransferase Saccharopolyspora erythraea NRRL 2338
dTDP-4-keto-6-deoxy-L-hexose 4-reductaseSaccharopolyspora erythraea NRRL 2338
EryCV NDP-4,6-dideoxyhexose 3,4-enoyl reductase Saccharopolyspora erythraea NRRL 2338
EryCIV NDP-6-deoxyhexose 3,4-dehydratase Saccharopolyspora erythraea NRRL 2338
6-DEB TDP-mycarosyl glycosyltransferase Saccharopolyspora erythraea NRRL 2338
NDP-hexose 2,3-enoyl reductase Saccharopolyspora erythraea NRRL 2338
EryBIII NDP-4-keto-2,6-dideoxyhexose 3-C-methyltransferaseSaccharopolyspora erythraea NRRL 2338
Cytochrome P450 family protein EryCIIErythromycin biosynthesis protein CIISaccharopolyspora erythraea NRRL 2338

Compounds (23)

CompoundDescription
diphosphoric acid
hydronium ion
Ammonium
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
ErythromycinA bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
thymidine 5'-triphosphateRN given refers to parent cpd
6-deoxyerythronolide bStreptomyces erythreus metabolite; presumed intermediate in biosynthesis of erythromycins; structure given in first source
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
alpha-Ketoglutarate
5'-deoxyadenosinemain heading DEOXYADENOSINE refers to the 3' cpd
glutamate
glucose-1-phosphateRN given refers to (alpha-D-Glc)-isomer
thymidine 5'-diphosphatesee also record for thymidine 3',5'-diphosphate, RN 2863-04-9
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
dTDP-4-amino-4,6-dideoxy-glucosestructure in first source
deoxythymidine diphosphate-glucosestructure given in first source
erythronolide bintermediate of erythromycin biogenesis; structure in first source
propionyl-coenzyme ARN given refers to parent cpd