Page last updated: 2024-10-06

superpathway of demethylmenaquinol-8 biosynthesis I

Proteins (11)

ProteinSynonymsTaxonomy
o-succinylbenzoate synthaseOSB synthase; OSBS; EC 4.2.1.113; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthaseEscherichia coli K-12
Octaprenyl diphosphate synthaseEC 2.5.1.90; All-trans-octaprenyl-diphosphate synthase; Octaprenyl pyrophosphate synthase; OPP synthaseEscherichia coli K-12
1,4-dihydroxy-2-naphthoate octaprenyltransferaseDHNA-octaprenyltransferase; EC 2.5.1.74Escherichia coli K-12
Isochorismate synthase MenFEC 5.4.4.2; Isochorismate hydroxymutase; Isochorismate mutaseEscherichia coli K-12
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseSHCHC synthase; EC 4.2.99.20Escherichia coli K-12
1,4-dihydroxy-2-naphthoyl-CoA synthaseDHNA-CoA synthase; EC 4.1.3.36Escherichia coli K-12
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseSEPHCHC synthase; EC 2.2.1.9; Menaquinone biosynthesis protein MenDEscherichia coli K-12
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseSEPHCHC synthase; EC 2.2.1.9; Menaquinone biosynthesis protein MenDEnterococcus faecalis V583
2-succinylbenzoate--CoA ligaseEC 6.2.1.26; o-succinylbenzoyl-CoA synthetase; OSB-CoA synthetaseEscherichia coli K-12
1,4-dihydroxy-2-naphthoyl-CoA hydrolaseDHNA-CoA hydrolase; EC 3.1.2.28; DHNA-CoA thioesteraseEscherichia coli K-12
2-succinylbenzoate--CoA ligaseEC 6.2.1.26; o-succinylbenzoyl-CoA synthetase; OSB-CoA synthetaseEnterococcus faecalis V583

Compounds (24)

CompoundDescription
diphosphoric acid
hydronium ion
Thiamine PyrophosphateThe coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.
MercuryA silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
hydrogen carbonate
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
nitratesInorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
1,4-dihydroxy-2-naphthoate
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
mercaptoethanolA water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
isopentenyl pyrophosphatesubstrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
farnesyl pyrophosphatea sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation
alpha-Ketoglutarate
diethyl pyrocarbonatePreservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
dithiothreitolA reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
isochorismate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Coenzyme A