Page last updated: 2024-10-06

superpathway of dTDP-glucose-derived antibiotic building blocks biosynthesis

Proteins (31)

ProteinSynonymsTaxonomy
Glucose-1-phosphate thymidylyltransferaseEC 2.7.7.24Streptomyces antibioticus
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydrataseEC 4.2.1.159; 2,3-dehydratase; dTDP-4-keto-6-deoxy-D-glucose 2,3-dehydrataseSaccharopolyspora spinosa
dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydrataseEC 4.2.1.164; Pyridoxamine 5'-monophosphate-dependent 3-dehydraseSaccharopolyspora spinosa
dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferaseEC 2.6.1.110; dTDP-4-keto-2,3,6-trideoxy-D-glucose 4-aminotransferaseSaccharopolyspora spinosa
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminaseEC 2.6.1.106
Probable dTDP-4,6-dihydroxy-2-methyloxan-3-one 4-ketoreductaseEC 1.1.1.-Streptomyces antibioticus
dTDP-glucose 4,6-dehydrataseEC 4.2.1.46Streptomyces antibioticus
Probable dTDP-4-oxo-2,6-dideoxy-D-glucose 3,5-epimeraseEC 5.1.3.-Streptomyces antibioticus
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductaseEC 1.1.1.384; dTDP-3,4-diketo-2,6-dideoxyglucose 3-ketoreductaseStreptomyces antibioticus
dTDP-glucose 4,6-dehydratase Saccharopolyspora spinosa
Glucose-1-phosphate thymidylyltransferase Saccharopolyspora erythraea NRRL 2338
D-mycarose 3-C-methyltransferaseStreptomyces argillaceus
KetoreductaseStreptomyces argillaceus
dTDP-glucose synthaseStreptomyces argillaceus
Glucose-1-phosphate thymidylyltransferase Saccharopolyspora spinosa
TDP-4-keto-6-deoxyglucose 2,3 dehydratase
TDP-4-keto-6-deoxyhexose 3,5-epimerase
dTDP-glucose 4,6-dehydratase Streptomyces argillaceus
dTDP-glucose 4,6-dehydratase Saccharopolyspora erythraea
TDP-4-keto-6-deoxyhexose 4-ketoreductase
Daunosaminyl-N,N-dimethyltransferase
D-olivose, D-oliose and D-mycarose 2,3-dehydrataseStreptomyces argillaceus
D-oliose 4-ketoreductaseStreptomyces argillaceus
TDP-4-keto-6-deoxyhexose 2,3-reductase
NDP-4-keto-6-deoxy-glucose 2,3-dehydratase Saccharopolyspora erythraea NRRL 2338
dTDP-4-keto-6-deoxy-L-hexose 4-reductaseSaccharopolyspora erythraea NRRL 2338
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductaseEC 1.1.1.384; dTDP-3,4-diketo-2,6-dideoxy-D-glucose 3-ketoreductaseSaccharopolyspora spinosa
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydrataseEC 4.2.1.159; 2,3-dehydrataseStreptomyces antibioticus
TDP-4-keto-6-deoxyglucose-2,3-dehydratase
NDP-hexose 2,3-enoyl reductase Saccharopolyspora erythraea NRRL 2338
EryBIII NDP-4-keto-2,6-dideoxyhexose 3-C-methyltransferaseSaccharopolyspora erythraea NRRL 2338

Compounds (13)

CompoundDescription
diphosphoric acid
hydronium ion
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
thymidine 5'-triphosphateRN given refers to parent cpd
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
alpha-Ketoglutarate
glutamate
glucose-1-phosphateRN given refers to (alpha-D-Glc)-isomer
thymidine 5'-diphosphatesee also record for thymidine 3',5'-diphosphate, RN 2863-04-9
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
deoxythymidine diphosphate-glucosestructure given in first source