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superpathway of cholesterol degradation I (cholesterol oxidase)

Proteins (11)

ProteinSynonymsTaxonomy
Cholesterol oxidaseCHOD; EC 1.1.3.6; Cholesterol isomerase; 5.3.3.1Brevibacterium sterolicum
4-hydroxy-2-oxovalerate aldolase 3HOA 3; EC 4.1.3.39; 4-hydroxy-2-keto-pentanoic acid aldolase 3; 4-hydroxy-2-oxopentanoate aldolase 3Rhodococcus jostii RHA1
Acetaldehyde dehydrogenase 3EC 1.2.1.10; Acetaldehyde dehydrogenase [acetylating] 3Rhodococcus jostii RHA1
3-ketosteroid-9-alpha-monooxygenase, oxygenase component3-ketosteroid-9-alpha-hydroxylase, oxygenase component; KSH; Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase; 1.14.15.30; Rieske-type oxygenase; RORhodococcus rhodochrous
3-oxocholest-4-en-26-oate--CoA ligaseEC 6.2.1.42; Steroid-CoA ligase; Steroid-coenzyme A ligaseRhodococcus rhodochrous
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligaseHIP:CoA ligase; EC 6.2.1.41Rhodococcus jostii RHA1
Flavin-dependent monooxygenase, oxygenase subunit HsaAEC 1.14.14.12; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4-hydroxylase, oxygenase subunit; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenaseRhodococcus jostii RHA1
Iron-dependent extradiol dioxygenaseEC 1.13.11.25Rhodococcus jostii RHA1
2-hydroxypentadienoate hydrataseRhodococcus jostii RHA1
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolaseEC 3.7.1.17; Meta-cleavage product hydrolase; MCP hydrolaseRhodococcus jostii RHA1
3-ketosteroid dehydrogenase Rhodococcus erythropolis

Compounds (28)

CompoundDescription
diphosphoric acid
hydronium ion
NADH
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
CholesterolThe principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
succinyl-coenzyme A
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
1,10-phenanthrolineRN given refers to parent cpd; inhibits Zn-dependent metalloproteinases
1,4-androstadiene-3,17-dionestructure
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
propionaldehydemay cause respiratory irritation; RN given refers to parent cpd; structure
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
cholest-5-en-3-one
Coenzyme A
flavin mononucleotide hydroquinonestructure in first source
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
propionyl-coenzyme ARN given refers to parent cpd
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
androstenedioneA delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
cholest-4-en-3-one