Page last updated: 2024-10-06

superpathway of aerobic toluene degradation

Proteins (38)

ProteinSynonymsTaxonomy
MetapyrocatechaseMPC; EC 1.13.11.2; CatO2ase; Catechol 2,3-dioxygenasePseudomonas putida
Aryl-alcohol dehydrogenaseEC 1.1.1.90; Benzyl alcohol dehydrogenase; BADHPseudomonas putida
4-hydroxy-2-oxovalerate aldolase 1HOA 1; EC 4.1.3.39; 4-hydroxy-2-keto-pentanoic acid aldolase 1; 4-hydroxy-2-oxopentanoate aldolase 1Pseudomonas putida F1
2-hydroxymuconic semialdehyde dehydrogenaseHMSD; EC 1.2.1.85Pseudomonas putida
4-oxalocrotonate decarboxylase4-OD; EC 4.1.1.77Pseudomonas putida
2-hydroxymuconate tautomeraseEC 5.3.2.6; 4-oxalocrotonate tautomerase; 4-OTPseudomonas putida
3-methylcatechol 2,3-dioxygenaseEC 1.13.11.-Pseudomonas putida F1
Cis-toluene dihydrodiol dehydrogenaseEC 1.3.1.-Pseudomonas putida F1
Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase componentEC 1.18.1.3Pseudomonas putida F1
Toluene-4-monooxygenase system, ferredoxin--NAD(+) reductase componentT4MO; EC 1.18.1.3; Ferredoxin--NAD(+) reductase; Toluene-4-monooxygenase systme, electron transfer componentPseudomonas mendocina
2-hydroxy-6-oxo-2,4-heptadienoate hydrolaseHOHH; EC 3.7.1.25Pseudomonas putida F1
1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenaseEC 1.3.1.25; 2-hydro-1,2-dihydroxybenzoate dehydrogenase; DHB dehydrogenase; Cis-1,2-dihydroxy-3,4-cyclohexadiene-1-carboxylate dehydrogenase; Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenasePseudomonas putida
Xylene monooxygenase subunit 1EC 1.14.15.-Pseudomonas putida
Toluate 1,2-dioxygenase subunit alphaEC 1.14.12.-Pseudomonas putida
Toluate 1,2-dioxygenase subunit betaEC 1.14.12.-Pseudomonas putida
Toluate 1,2-dioxygenase electron transfer componentPseudomonas putida
2-hydroxypent-2,4-dienoate hydrataseHPH; EC 4.2.-.-; 2-oxopent-4-enoate hydratasePseudomonas putida
Benzaldehyde dehydrogenase [NAD(+)]EC 1.2.1.28Pseudomonas putida
Toluene-4-monooxygenase system, hydroxylase component subunit alphaT4MO; EC 1.14.13.236; Toluene-4-monooxygenase hydroxylase subunit; T4moH; Toluene-4-monooxygenase system protein A; T4moAPseudomonas mendocina
Toluene-4-monooxygenase system, hydroxylase component subunit gammaT4MO; EC 1.14.13.236; Toluene-4-monooxygenase hydroxylase subunit; T4moH; Toluene-4-monooxygenase system protein B; T4moBPseudomonas mendocina
Toluene-4-monooxygenase system, hydroxylase component subunit betaT4MO; EC 1.14.13.236; Toluene-4-monooxygenase hydroxylase subunit; T4moH; Toluene-4-monooxygenase system protein E; T4moEPseudomonas mendocina
Catechol 2,3-dioxygenase Ralstonia pickettii
Acetaldehyde dehydrogenase Pseudomonas putida
Ferredoxin subunitRalstonia pickettii
TomA4Burkholderia cepacia
Alpha hydroxylase subunit Ralstonia pickettii
Beta hydroxylase subunit Ralstonia pickettii
TomA3Burkholderia cepacia
TomA5Burkholderia cepacia
2-hydroxymuconate semialdehyde hydrolaseHMSH; EC 3.7.1.9; 2-hydroxymuconic semialdehyde hydrolasePseudomonas putida
Gamma hydroxylase subunitRalstonia pickettii
Effector subunit Ralstonia pickettii
Reductase subunitRalstonia pickettii
TomA2Burkholderia cepacia
TomA1Burkholderia cepacia
Toluene-4-monooxygenase system, effector componentT4MO; Toluene-4-monooxygenase effector protein; Toluene-4-monooxygenase system protein D; T4moDPseudomonas mendocina
Toluene 1,2-dioxygenase system ferredoxin subunitPseudomonas putida F1
Toluene-4-monooxygenase system, ferredoxin componentT4MO; Toluene-4-monooxygenase system protein C; T4moCPseudomonas mendocina

Compounds (32)

CompoundDescription
hydronium ion
tolueneA widely used industrial solvent.
Succinate
NADH
benzyl alcoholA colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
4-cresolRN given refers to parent cpd
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
succinyl-coenzyme A
nedocromilA pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including EOSINOPHILS; NEUTROPHILS; MACROPHAGES; MAST CELLS; MONOCYTES; AND PLATELETS.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
4-hydroxybenzyl alcoholthe aglycone of gastrodin
4-hydroxybenzaldehyde
4-hydroxybenzoic acid
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
acetaldehydeA colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
benzaldehydeRN given refers to parent cpd; structure
Benzoate
formate
catecholRN given refers to unlabeled parent cpd
2-cresolRN given refers to parent cpd
3-methylcatechol
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
4-methylcatecholstructure