Page last updated: 2024-10-06

superpathway of NAD biosynthesis in eukaryotes

Proteins (11)

ProteinSynonymsTaxonomy
Kynurenine 3-monooxygenaseEC 1.14.13.9; Biosynthesis of nicotinic acid protein 4; Kynurenine 3-hydroxylaseSaccharomyces cerevisiae S288C
3-hydroxyanthranilate 3,4-dioxygenaseEC 1.13.11.6; 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD; Biosynthesis of nicotinic acid protein 1Saccharomyces cerevisiae S288C
NicotinamidaseEC 3.5.1.19; Nicotinamide deamidase; NAMaseSaccharomyces cerevisiae S288C
Nicotinamide riboside kinaseNRK; NmR-K; EC 2.7.1.22; Nicotinic acid riboside kinase; 2.7.1.173; Ribosylnicotinamide kinase; RNK; Ribosylnicotinic acid kinaseSaccharomyces cerevisiae S288C
NAD-dependent histone deacetylase SIR2EC 2.3.1.286; Regulatory protein SIR2; Silent information regulator 2Saccharomyces cerevisiae S288C
Indoleamine 2,3-dioxygenaseIDO; EC 1.13.11.52; Biosynthesis of nicotinic acid protein 2Saccharomyces cerevisiae S288C
Probable kynurenine--oxoglutarate transaminase BNA3EC 2.6.1.7; Biosynthesis of nicotinic acid protein 3; Kynurenine aminotransferaseSaccharomyces cerevisiae S288C
KynureninaseEC 3.7.1.3; Biosynthesis of nicotinic acid protein 5; L-kynurenine hydrolaseSaccharomyces cerevisiae S288C
Nicotinate-nucleotide pyrophosphorylase [carboxylating]EC 2.4.2.19; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTaseSaccharomyces cerevisiae S288C
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2NMN/NaMN adenylyltransferase 2; EC 2.7.7.1; EC 2.7.7.18; NAD(+) diphosphorylase 2; NAD(+) pyrophosphorylase 2; Nicotinamide-nucleotide adenylyltransferase 2; NMN adenylyltransferase 2; NMNAT 2; Nicotinate-nucleotide adenylyltransferase 2; NaMN adenylyltraSaccharomyces cerevisiae S288C
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1NMN/NaMN adenylyltransferase 1; EC 2.7.7.1; EC 2.7.7.18; NAD(+) diphosphorylase 1; NAD(+) pyrophosphorylase 1; Nicotinamide-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NMNAT 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltraSaccharomyces cerevisiae S288C

Compounds (24)

CompoundDescription
diphosphoric acid
hydronium ion
Ammonium
MercuryA silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
NickelA trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Nico-400
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
formate
nicotinamide-beta-riboside
glutamate
Quinolinate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer
nicotinic acid adenine dinucleotideintermediate in the biosynthesis of NAD
nicotinate mononucleotide