Page last updated: 2024-10-06

sphingosine and sphingosine-1-phosphate metabolism

Proteins (11)

ProteinSynonymsTaxonomy
Neutral ceramidaseN-CDase; NCDase; EC 3.5.1.-; EC 3.5.1.23; Acylsphingosine deacylase 2; N-acylsphingosine amidohydrolase 2Mus musculus (house mouse)
Aldehyde dehydrogenase family 3 member A2EC 1.2.1.3; EC 1.2.1.94; Aldehyde dehydrogenase 10; Fatty aldehyde dehydrogenase; Microsomal aldehyde dehydrogenaseHomo sapiens (human)
Sphingosine kinase 1SK 1; SPK 1; EC 2.7.1.91; Acetyltransferase SPHK1; 2.3.1.-Mus musculus (house mouse)
Sphingosine-1-phosphate lyase 1S1PL; SP-lyase 1; SPL 1; mSPL; EC 4.1.2.27; Sphingosine-1-phosphate aldolaseMus musculus (house mouse)
Long-chain-fatty-acid--CoA ligase 1EC 6.2.1.3; Acyl-CoA synthetase 1; ACS1; Arachidonate--CoA ligase; 6.2.1.15; Long-chain acyl-CoA synthetase 1; LACS 1; Long-chain acyl-CoA synthetase 2; LACS 2; Long-chain fatty acid-CoA ligase 2; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2; Phytanate-Homo sapiens (human)
Sphingosine kinase 2SK 2; SPK 2; EC 2.7.1.91Mus musculus (house mouse)
Sphingosine-1-phosphate phosphatase 1SPP; SPPase1; mSPP1; EC 3.1.3.-; Sphingosine-1-phosphatase 1Mus musculus (house mouse)
Fatty aldehyde dehydrogenase HFD1EC 1.2.1.3Saccharomyces cerevisiae S288C
Acid ceramidaseAC; ACDase; Acid CDase; EC 3.5.1.23; Acylsphingosine deacylase; N-acylethanolamine hydrolase ASAH1; 3.5.1.-; N-acylsphingosine amidohydrolaseMus musculus (house mouse)
Prostaglandin reductase 1PRG-1; 15-oxoprostaglandin 13-reductase; 1.3.1.48; Dithiolethione-inducible gene 1 protein; D3T-inducible gene 1 protein; DIG-1; Leukotriene B4 12-hydroxydehydrogenase; NAD(P)H-dependent alkenal/one oxidoreductase; 1.3.1.74Mus musculus (house mouse)
Alkaline ceramidase 1AlkCDase 1; Alkaline CDase 1; maCER1; EC 3.5.1.-; EC 3.5.1.23; Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3Mus musculus (house mouse)

Compounds (17)

CompoundDescription
diphosphoric acid
hydronium ion
NADH
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
2-hexadecenal
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
hexadecanal
Coenzyme A
Palmitoyl Coenzyme AA fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis.
SphingosineAn amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)
sphingosine 1-phosphateRN given refers to (R-(R*,S*-(E)))-isomer; RN for cpd without isomeric designation not available 8/89