Page last updated: 2024-10-06

sphingolipid biosynthesis (mammals)

Proteins (9)

ProteinSynonymsTaxonomy
Phosphatidylcholine:ceramide cholinephosphotransferase 1EC 2.7.8.27; Protein Mob; Sphingomyelin synthase 1; Transmembrane protein 23Mus musculus (house mouse)
Serine palmitoyltransferase 1EC 2.3.1.50; Long chain base biosynthesis protein 1; LCB 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1Homo sapiens (human)
Serine palmitoyltransferase 2EC 2.3.1.50; Long chain base biosynthesis protein 2; LCB 2; Long chain base biosynthesis protein 2a; LCB2a; Serine-palmitoyl-CoA transferase 2; SPT 2Homo sapiens (human)
Sphingolipid delta(4)-desaturase DES1EC 1.14.19.17; Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; Dihydroceramide desaturase-1; Membrane lipid desaturaseHomo sapiens (human)
Phosphatidylcholine:ceramide cholinephosphotransferase 2EC 2.7.8.27; Sphingomyelin synthase 2Mus musculus (house mouse)
3-ketodihydrosphingosine reductaseKDS reductase; EC 1.1.1.102; 3-dehydrosphinganine reductase; Follicular variant translocation protein 1; FVT-1; Short chain dehydrogenase/reductase family 35C member 1Homo sapiens (human)
Serine palmitoyltransferase 3EC 2.3.1.50; Long chain base biosynthesis protein 2b; LCB2b; Long chain base biosynthesis protein 3; LCB 3; Serine-palmitoyl-CoA transferase 3; SPT 3Homo sapiens (human)
Ceramide synthase 1CerS1; EC 2.3.1.-; LAG1 longevity assurance homolog 1; Longevity assurance gene 1 protein homolog 1; Protein UOG-1Homo sapiens (human)
Serine palmitoyltransferase small subunit ASmall subunit of serine palmitoyltransferase A; ssSPTaHomo sapiens (human)

Compounds (12)

CompoundDescription
hydronium ion
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
PhosphorylcholineCalcium and magnesium salts used therapeutically in hepatobiliary dysfunction.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Coenzyme A
sphingosine phosphorylcholinea wound healing agent
Palmitoyl Coenzyme AA fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis.
sphinganine
dihydroceramidelacks the 4-5 trans double bond of the sphingosine moiety of ceramides; structure in first source