| Protein | Synonyms | Taxonomy |
|---|
| Cheilanthifoline synthase | CHS; EC 1.14.19.65; Cytochrome P450 719A5 | Eschscholzia californica (California poppy) |
| Protopine 6-monooxygenase | EC 1.14.14.98; Protopine 6-hydroxylase; P6H | Eschscholzia californica (California poppy) |
| Reticuline oxidase | EC 1.21.3.3; Berberine bridge-forming enzyme; BBE; Tetrahydroprotoberberine synthase | Eschscholzia californica (California poppy) |
| Reticuline oxidase | EC 1.21.3.3; Berberine bridge-forming enzyme; BBE; Tetrahydroprotoberberine synthase | Papaver somniferum (opium poppy) |
| Sanguinarine reductase | EC 1.3.1.107 | Eschscholzia californica (California poppy) |
| Methyltetrahydroprotoberberine 14-monooxygenase | EC 1.14.14.97; (S)-cis-N-methylstylopine 14-hydroxylase; (S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase; Methyltetrahydroprotoberberine 14-hydroxylase; N-methylstylopine hydroxylase; MSH | Papaver somniferum (opium poppy) |
| Compound | Description |
|---|
| hydronium ion | |
| Cobalt | A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis. |
| NADH | |
| Copper | A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55. |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| Manganese | A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035) |
| metyrapone | An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME. |
| Ketoconazole | Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. |
| dicumarol | An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases. |
| Hydrogen Peroxide | A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. |
| Nickel | A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| discretamine | structure |
| mercaptoethanol | A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation. |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| hydrazoic acid | |
| protopine | RN given refers to parent cpd; structure |
| sanguinarine | bactericidal produces glaucoma in laboratory animals; a phytogenic antineoplastic agent; from Argemonemexicana & Sanguinaria; inhibits glutamate decarboxylase; structure |
| potassium cyanide | A highly poisonous compound that is an inhibitor of many metabolic processes, but has been shown to be an especially potent inhibitor of heme enzymes and hemeproteins. It is used in many industrial processes. |
| dihydrosanguinarine | alkaloid from the herb, Corydalis adunca; structure in first source |
| chelirubine | RN given refers to parent cpd |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| Ditiocarb | A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM. |
| Flavin-Adenine Dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |