Page last updated: 2024-10-06

pyruvate fermentation to isobutanol (engineered)

Proteins (17)

ProteinSynonymsTaxonomy
Ketol-acid reductoisomerase (NADP(+))KARI; EC 1.1.1.86; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 2; Ketol-acid reductoisomerase type IIEscherichia coli K-12
Pyruvate decarboxylase isozyme 1EC 4.1.1.-; EC 4.1.1.43; EC 4.1.1.72; EC 4.1.1.74; Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase; 2ODCSaccharomyces cerevisiae S288C
Pyruvate decarboxylase isozyme 2EC 4.1.1.-; EC 4.1.1.43; EC 4.1.1.72; EC 4.1.1.74; Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase; 2ODCSaccharomyces cerevisiae S288C
Pyruvate decarboxylase isozyme 3EC 4.1.1.-; EC 4.1.1.43; EC 4.1.1.72; EC 4.1.1.74; Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase; 2ODCSaccharomyces cerevisiae S288C
Alcohol dehydrogenase 1EC 1.1.1.1; Alcohol dehydrogenase I; YADH-1Saccharomyces cerevisiae S288C
Alcohol dehydrogenase 2EC 1.1.1.1; Alcohol dehydrogenase II; YADH-2Saccharomyces cerevisiae S288C
Acetolactate synthase isozyme 3 large subunitEC 2.2.1.6; AHAS-III; ALS-III; Acetohydroxy-acid synthase III large subunitEscherichia coli K-12
Acetolactate synthase isozyme 3 small subunitEC 2.2.1.6; ALS-III; Acetohydroxy-acid synthase III small subunit; AHAS-IIIEscherichia coli K-12
Alcohol dehydrogenase 3, mitochondrialEC 1.1.1.1; Alcohol dehydrogenase III; YADH-3Saccharomyces cerevisiae S288C
Acetolactate synthase isozyme 1 large subunitAHAS-I; EC 2.2.1.6; Acetohydroxy-acid synthase I large subunit; ALS-IEscherichia coli K-12
Acetolactate synthase isozyme 1 small subunitEC 2.2.1.6; Acetohydroxy-acid synthase I small subunit; AHAS-I; ALS-IEscherichia coli K-12
Acetolactate synthase isozyme 2 small subunitEC 2.2.1.6; ALS-II; Acetohydroxy-acid synthase II small subunit; AHAS-IIEscherichia coli K-12
Alcohol dehydrogenase 4EC 1.1.1.1; Alcohol dehydrogenase IV; ADHIVSaccharomyces cerevisiae S288C
Alcohol dehydrogenase 5EC 1.1.1.1; Alcohol dehydrogenase VSaccharomyces cerevisiae S288C
Dihydroxy-acid dehydrataseDAD; EC 4.2.1.9Escherichia coli K-12
Putative acetolactate synthase isozyme 2 large subunit AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunitEscherichia coli K-12
Alpha-ketoisovalerate decarboxylaseLactococcus lactis subsp. lactis

Compounds (17)

CompoundDescription
hydronium ion
Thiamine PyrophosphateThe coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.
NADH
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
2-ketobutyrate
glyoxylate
alpha-keto-isovaleric acid
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
isobutyl alcoholRN given refers to parent cpd
isobutyraldehyde
Hoe 704