Page last updated: 2024-10-06

protocatechuate degradation I (meta-cleavage pathway)

Proteins (15)

ProteinSynonymsTaxonomy
4-hydroxy-4-methyl-2-oxoglutarate aldolase/4-carboxy-4-hydroxy-2-oxoadipate aldolaseHMG/CHA aldolase; EC 4.1.3.16; EC 4.1.3.17; 4-hydroxy-2-oxoglutarate aldolase; Oxaloacetate decarboxylase; OAA decarboxylase; 4.1.1.112Pseudomonas straminea
4-carboxy-4-hydroxy-2-oxoadipate aldolaseSphingomonas paucimobilis
2-pyrone-4,6-dicarboxylate hydrolasePDC hydrolase; EC 3.1.1.57; 2-pyrone-4,6-dicarboxylate lactonaseSphingobium sp. SYK-6
2-pyrone-4,6-dicarbaxylate hydrolasePDC hydrolase; EC 3.1.1.57; 2-pyrone-4,6-dicarboxylate lactonaseComamonas testosteroni
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenaseCHMS dehydrogenase; EC 1.1.1.312; 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenaseSphingobium sp. SYK-6
PmdEComamonas testosteroni
Protocatechuate 4,5-dioxygenase beta chain Comamonas testosteroni
PmdFComamonas testosteroni
4-Oxalomesaconate hydratase Pseudomonas straminea
2-pyrone-4,6-dicarboxylate lactonase Pseudomonas straminea
Protocatechuate 4,5-dioxygenase alpha subunit Comamonas testosteroni
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase Pseudomonas straminea
Protocatechuate 4,5-dioxygenase alpha chainEC 1.13.11.8; 4,5-PCDSphingobium sp. SYK-6
Protocatechuate 4,5-dioxygenase beta chainEC 1.13.11.8; 4,5-PCDSphingobium sp. SYK-6
4-oxalomesaconate hydrataseSphingomonas paucimobilis

Compounds (22)

CompoundDescription
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
copper sulfateA sulfate salt of copper. It is a potent emetic and is used as an antidote for poisoning by phosphorus. It also can be used to prevent the growth of algae.
MercuryA silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
CopperA heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
NickelA trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
nedocromilA pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including EOSINOPHILS; NEUTROPHILS; MACROPHAGES; MAST CELLS; MONOCYTES; AND PLATELETS.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
OxaloacetateAn anionic form of oxaloacetic acid.
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
CysteineA thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
4-oxalmesaconic acidstructure given in first source
alpha-pyrone-4,6-dicarboxylic acidstructure