Page last updated: 2024-10-06

peptidoglycan biosynthesis II (staphylococci)

Proteins (20)

ProteinSynonymsTaxonomy
Phospho-N-acetylmuramoyl-pentapeptide-transferaseEC 2.7.8.13; UDP-MurNAc-pentapeptide phosphotransferaseStaphylococcus aureus
Penicillin-binding protein 4Staphylococcus aureus
Cell division protein FtsI Staphylococcus aureus
MecA Staphylococcus aureus
UDP-N-acetylmuramate--L-alanine ligaseEC 6.3.2.8; UDP-N-acetylmuramoyl-L-alanine synthetaseStaphylococcus aureus
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1EC 2.5.1.7; Enoylpyruvate transferase 1; UDP-N-acetylglucosamine enolpyruvyl transferase 1; EPT 1Staphylococcus aureus subsp. aureus N315
Cell division protein FtsI [Peptidoglycan synthetase] / Transpeptidase, Penicillin binding protein transpeptidase domain, Penicillin-binding protein 3 Staphylococcus aureus
Monofunctional glycosyltransferaseMGT; EC 2.4.1.129; Peptidoglycan TGaseStaphylococcus aureus subsp. aureus NCTC 8325
Glutamate racemaseEC 5.1.1.3Staphylococcus haemolyticus
UDP-N-acetylmuramoylalanine--D-glutamate ligaseEC 6.3.2.9; D-glutamic acid-adding enzyme; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseStaphylococcus aureus
UDP-N-acetylenolpyruvoylglucosamine reductaseEC 1.3.1.98; UDP-N-acetylmuramate dehydrogenaseStaphylococcus aureus
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Staphylococcus aureus subsp. aureus NCTC 8325
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligaseEC 6.3.2.7; L-lysine-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:L-Lys ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetaseStaphylococcus aureus subsp. aureus COL
Aminoacyltransferase FemAEC 2.3.2.17; Factor essential for expression of methicillin resistance A; N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferaseStaphylococcus aureus
Aminoacyltransferase FemBEC 2.3.2.18; Factor essential for expression of methicillin resistance B; N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferaseStaphylococcus aureus
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2EC 2.5.1.7; Enoylpyruvate transferase 2; UDP-N-acetylglucosamine enolpyruvyl transferase 2; EPT 2Staphylococcus aureus subsp. aureus N315
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseEC 2.4.1.227; Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseStaphylococcus aureus subsp. aureus COL
Lipid II:glycine glycyltransferaseEC 2.3.2.16; Factor essential for expression of methicillin resistance XStaphylococcus aureus subsp. aureus Mu50
D-alanine--D-alanine ligaseEC 6.3.2.4; D-Ala-D-Ala ligase; D-alanylalanine synthetaseStaphylococcus aureus subsp. aureus COL
DD-transpeptidase Staphylococcus aureus

Compounds (21)

CompoundDescription
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
Ammonium
MethicillinOne of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
D-Glutamate
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
CycloserineAntibiotic substance produced by Streptomyces garyphalus.
Uridine Monophosphate5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
uridine diphosphate n-acetylmuramic acidA nucleoside diphosphate sugar which is formed from UDP-N-acetylglucosamine and phosphoenolpyruvate. It serves as the building block upon which peptidoglycan is formed.
lipid II
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)