| Protein | Synonyms | Taxonomy |
|---|
| Glucose-1-phosphate thymidylyltransferase | EC 2.7.7.24; Novobiocin biosynthesis protein V; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase | Streptomyces niveus |
| 8-demethylnovobiocic acid synthase | EC 6.3.1.15; 8-demethylnovobiocic acid synthetase; Novobiocic acid synthetase; Novobiocin biosynthesis protein L; Novobiocin ligase | Streptomyces niveus |
| Demethyldecarbamoylnovobiocin O-methyltransferase | EC 2.1.1.285; Novobiocin biosynthesis protein P | Streptomyces niveus |
| 8-demethylnovobiocic acid C(8)-methyltransferase | EC 2.1.1.284; Novobiocin biosynthesis protein O | Streptomyces niveus |
| C-methyltransferase NovU | EC 2.1.1.-; Novobiocin biosynthesis protein U | Streptomyces niveus |
| dTDP-glucose 4,6-dehydratase | EC 4.2.1.46; Novobiocin biosynthesis protein T | Streptomyces niveus |
| dTDP-4-keto-6-deoxy-D-glucose reductase | EC 1.1.1.-; Novobiocin biosynthesis protein S | Streptomyces niveus |
| Decarboxylase NovR | EC 4.1.-.-; Novobiocin biosynthesis protein R | Streptomyces niveus |
| Decarbamoylnovobiocin carbamoyltransferase | EC 2.1.3.12; Novobiocin biosynthesis protein N | Streptomyces niveus |
| L-demethylnoviosyl transferase | EC 2.4.1.302; Novobiocin biosynthesis protein M | Streptomyces niveus |
| Short-chain reductase protein NovJ | EC 1.1.1.-; Novobiocin biosynthesis protein J | Streptomyces niveus |
| Cytochrome P450 NovI | EC 1.14.-.-; Novobiocin biosynthesis protein I | Streptomyces niveus |
| Novobiocin biosynthesis protein H | EC 6.-.-.- | Streptomyces niveus |
| Probable prephenate dehydrogenase NovF | EC 1.3.1.12; Novobiocin biosynthesis protein F | Streptomyces niveus |
| dTDP-4-dehydrorhamnose 3-epimerase | EC 5.1.3.-; Novobiocin biosynthesis protein W; dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase | Streptomyces niveus |
| 4-hydroxyphenylpyruvate 3-dimethylallyltransferase | EC 2.5.1.111; 4HPP 3-dimethylallyltransferase; Aromatic prenyltransferase NovQ; Dimethylallyl diphosphate:4-hydroxyphenylpyruvate dimethylallyl transferase; Novobiocin biosynthesis protein Q | Streptomyces niveus |
| Short-chain dehydrogenase/reductase family member NovK | Novobiocin biosynthesis protein K | Streptomyces niveus |
| Compound | Description |
|---|
| diphosphoric acid | |
| hydronium ion | |
| novobiocin | An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) |
| NADH | |
| iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Manganese | A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035) |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| Orthophosphate | |
| Magnesium | A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| thymidine 5'-triphosphate | RN given refers to parent cpd |
| adenosine monophosphate | Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| Carbamyl Phosphate | The monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING). |
| prephenate | |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| 4-hydroxyphenylpyruvate | |
| glucose-1-phosphate | RN given refers to (alpha-D-Glc)-isomer |
| thymidine 5'-diphosphate | see also record for thymidine 3',5'-diphosphate, RN 2863-04-9 |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| deoxythymidine diphosphate-glucose | structure given in first source |