Pathways > nicotine degradation III
Page last updated: 2024-10-06

nicotine degradation III

Proteins (43)

ProteinSynonymsTaxonomy
Cytochrome P450 2A5EC 1.14.14.1; CYPIIA5; Coumarin 7-hydroxylase; Cytochrome P450-15-COH; Cytochrome P450-IIA3.2Mus musculus (house mouse)
Cytochrome P450 1A2EC 1.14.14.1; CYPIA2; Cholesterol 25-hydroxylase; Cytochrome P450-P2; Cytochrome P450-P3; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152Mus musculus (house mouse)
Aldehyde oxidase 1EC 1.2.3.1; Azaheterocycle hydroxylase 1; 1.17.3.-; Retinal oxidaseMus musculus (house mouse)
Cytochrome P450 1A1EC 1.14.14.1; CYPIA1; Cytochrome P450 form 6; Cytochrome P450-C; Cytochrome P450-P1; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152Mus musculus (house mouse)
Cytochrome P450 2B10EC 1.14.14.1; CYPIIB10; CYPIIB20; Cytochrome P450 2B20; Cytochrome P450 clone PF3/46; Cytochrome P450-16-alpha; P24; Testosterone 16-alpha hydroxylaseMus musculus (house mouse)
UDP-glucuronosyltransferase 1A1UGT1A1; EC 2.4.1.17; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UGTBR1Mus musculus (house mouse)
Cytochrome P450 3A11EC 1.14.14.1; CYPIIIA11; Cytochrome P-450IIIAM1; Cytochrome P-450UTMus musculus (house mouse)
Cytochrome P450 1B1EC 1.14.14.1; CYPIB1; Cytochrome P450CMEF; Cytochrome P450EF; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152Mus musculus (house mouse)
Cytochrome P450 2S1EC 1.14.14.-; CYPIIS1; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152; Thromboxane-A synthase; 5.3.99.5Mus musculus (house mouse)
Cytochrome P450 3A25EC 1.14.14.1; CYPIIIA25Mus musculus (house mouse)
Cytochrome P450 2J5EC 1.14.14.1; Arachidonic acid epoxygenase; CYPIIJ5Mus musculus (house mouse)
Cytochrome P450 2J6EC 1.14.14.1; Arachidonic acid epoxygenase; CYPIIJ6Mus musculus (house mouse)
Cytochrome P450 2B19EC 1.14.14.1; CYPIIB19Mus musculus (house mouse)
Cytochrome P450 2D9EC 1.14.14.1; CYPIID9; Cytochrome P450-16-alpha; Cytochrome P450CA; Testosterone 16-alpha hydroxylaseMus musculus (house mouse)
Cytochrome P450 2B9EC 1.14.14.1; CYPIIB9; Cytochrome P450 clone PF26; Cytochrome P450-16-alpha; Testosterone 16-alpha hydroxylaseMus musculus (house mouse)
Cytochrome P450 2A4EC 1.14.14.1; CYPIIA4; Cytochrome P450-15-alpha; Cytochrome P450-IIA3.1; Testosterone 15-alpha-hydroxylaseMus musculus (house mouse)
Cytochrome P450 2D10EC 1.14.14.1; CYPIID10; Cytochrome P450-16-alpha; Cytochrome P450CB; Testosterone 16-alpha hydroxylaseMus musculus (house mouse)
Cytochrome P450 2D11EC 1.14.14.1; CYPIID11; Cytochrome P450-16-alpha; Cytochrome P450CC; Testosterone 16-alpha hydroxylaseMus musculus (house mouse)
Cytochrome P450 2A12EC 1.14.14.1; CYPIIA12; Steroid hormones 7-alpha-hydroxylase; Testosterone 7-alpha-hydroxylaseMus musculus (house mouse)
Cytochrome P450 2C37EC 1.14.14.1; CYPIIC37Mus musculus (house mouse)
Cytochrome P450 2C38EC 1.14.14.1; CYPIIC38Mus musculus (house mouse)
Cytochrome P450 2C39EC 1.14.14.1; CYPIIC39Mus musculus (house mouse)
Cytochrome P450 2E1EC 1.14.14.1; 4-nitrophenol 2-hydroxylase; 1.14.13.n7; CYPIIE1; Cytochrome P450-ALC; Cytochrome P450-JMus musculus (house mouse)
Cytochrome P450 2C29EC 1.14.14.1; Aldehyde oxygenase; CYPIIC29; Cytochrome P-450 MUT-2Mus musculus (house mouse)
Cytochrome P450 4B1EC 1.14.14.1; CYPIVB1Mus musculus (house mouse)
Cytochrome P450 3A13EC 1.14.14.1; CYPIIIA13Mus musculus (house mouse)
Cytochrome P450 3A16EC 1.14.14.1; CYPIIIA16Mus musculus (house mouse)
Cytochrome P450 2C54EC 1.14.14.1; CYPIIC54Mus musculus (house mouse)
Cytochrome P450 2D26EC 1.14.14.1; CYPIID26Mus musculus (house mouse)
Cytochrome P450 4A12AEC 1.14.14.1; CYPIVA12Mus musculus (house mouse)
Cytochrome P450 2C50EC 1.14.14.1; CYPIIC50Mus musculus (house mouse)
Cytochrome P450 2C55EC 1.14.14.1; CYPIIC55Mus musculus (house mouse)
Cytochrome P450 3A41EC 1.14.14.1Mus musculus (house mouse)
UDP-glucuronosyltransferase 2B17UGT2B17; EC 2.4.1.17; M-1; UDP-glucuronosyltransferase 2B5; UDPGT 2B5Mus musculus (house mouse)
AromataseEC 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthaseMus musculus (house mouse)
UDP-glucuronosyltransferase 3A1UDPGT 3A1; EC 2.4.1.17Mus musculus (house mouse)
UDP-glucuronosyltransferase 1A9UGT1A9; EC 2.4.1.17; UDP-glucuronosyltransferase 1-7; UDPGT; UDP-glucuronosyltransferase 1-9; UDPGT 1-9; UGT1*9; UGT1-09; UGT1.9; UGT1A12; UGTP4Mus musculus (house mouse)
UDP-glucuronosyltransferase 1-6UDPGT 1-6; UGT1*6; UGT1-06; UGT1.6; EC 2.4.1.17; Phenol UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1A6; UGT1A6; UGP1A1; UGT1A7Mus musculus (house mouse)
UDP-glucuronosyltransferase 1A7UGT1A7; EC 2.4.1.17; UDP-glucuronosyltransferase 1-7C; UDPGT 1-7C; UGT1*7C; UGT1-07C; UGT1.7C; UDP-glucuronosyltransferase 1A7CMus musculus (house mouse)
UDP-glucuronosyltransferase 3A2UDPGT 3A2; EC 2.4.1.17Mus musculus (house mouse)
Cytochrome P450 2C40EC 1.14.14.-; CYPIIC40Mus musculus (house mouse)
Cytochrome P450 2C70EC 1.14.14.-; CYPIIC70Mus musculus (house mouse)
Cytochrome P450 2U1Long-chain fatty acid omega-monooxygenase; 1.14.14.80Mus musculus (house mouse)

Compounds (15)

CompoundDescription
hydronium ion
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
norcotinine, (S)-isomer
nicotine iminium
hydroxycotininemetabolite of nicotine; RN given refers to (S)-isomer; structure
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
4-(3-pyridyl)-4-oxobutyramidemetabolite of nicotine and cotinine
oxoamidecotinine metabolite; structure given in first source
cotinine-N-oxidemetabolite of nicotine; structure
N-hydroxymethylnorcotininea primary in vitro metabolite of cotinine; structure given in first source
cotinineThe N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.
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