Page last updated: 2024-10-06

nicotine degradation I (pyridine pathway)

Proteins (13)

ProteinSynonymsTaxonomy
6-hydroxy-L-nicotine oxidase Paenarthrobacter nicotinovorans
4-methylaminobutanoate oxidase (formaldehyde-forming)MABO; EC 1.5.3.19; Demethylating gamma-N-methylaminobutyrate oxidase; Gamma-N-methylaminobutyrate oxidase 1Paenarthrobacter nicotinovorans
4-methylaminobutanoate oxidase (methylamine-forming)EC 1.5.3.21; Gamma-N-methylaminobutyrate oxidase 2Paenarthrobacter nicotinovorans
Aldehyde dehydrogenaseEC 1.2.1.3; EC 1.2.1.4; NAD/NADP-dependent aldehyde dehydrogenasePaenarthrobacter nicotinovorans
2-oxoglutaramate amidaseEC 3.5.1.111; Omega-amidasePaenarthrobacter nicotinovorans
2,6-dihydroxypyridine 3-monooxygenase2,6-DHPH; EC 1.14.13.10Paenarthrobacter nicotinovorans
6-hydroxypseudooxynicotine dehydrogenase complex subunit alphaEC 1.5.99.14; Ketone dehydrogenase medium FAD subunitPaenarthrobacter nicotinovorans
6-hydroxypseudooxynicotine dehydrogenase complex subunit betaEC 1.5.99.14; Ketone dehydrogenase small FeS subunitPaenarthrobacter nicotinovorans
Nicotine dehydrogenase Paenarthrobacter nicotinovorans
NdhS Paenarthrobacter nicotinovorans
NdhM Paenarthrobacter nicotinovorans
6-hydroxypseudooxynicotine dehydrogenase complex subunit gammaEC 1.5.99.14; Ketone dehydrogenase large molybdopterin subunitPaenarthrobacter nicotinovorans
NADPaenarthrobacter nicotinovorans

Compounds (23)

CompoundDescription
hydronium ion
ureaA compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Succinate
NADH
Ammonium
MercuryA silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
formaldehydeA highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
alpha-Ketoglutarate
tungstate
glutamate
4-ChloromercuribenzenesulfonateA cytotoxic sulfhydryl reagent that inhibits several subcellular metabolic systems and is used as a tool in cellular physiology.
2,6-dihydroxypyridineinhibits dihydropyrimidine dehydrogenase
alpha-ketoglutaramatedeaminated metabolite of glutamine in csf of patients with hepatic coma; intermediate in the detoxification of ammonia in brain; structure
2,3-dihydroxypyridineaffects thyroid function
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
methylammonium ion