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methylerythritol phosphate pathway I

Proteins (9)

ProteinSynonymsTaxonomy
4-hydroxy-3-methylbut-2-enyl diphosphate reductaseHMBPP reductase; EC 1.17.7.4; 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductaseEscherichia coli K-12
1-deoxy-D-xylulose 5-phosphate reductoisomeraseDXP reductoisomerase; EC 1.1.1.267; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthaseEscherichia coli K-12
4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseCMK; EC 2.7.1.148; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinaseEscherichia coli K-12
1-deoxy-D-xylulose-5-phosphate synthaseEC 2.2.1.7; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPSEscherichia coli K-12
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseMECDP-synthase; MECPP-synthase; MECPS; EC 4.6.1.12Escherichia coli K-12
Isopentenyl-diphosphate Delta-isomeraseIPP isomerase; EC 5.3.3.2; IPP:DMAPP isomerase; Isopentenyl pyrophosphate isomeraseEscherichia coli K-12
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)EC 1.17.7.3; 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Protein GcpE; Protein EEscherichia coli K-12
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseEC 2.7.7.60; 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; CDP-ME synthase; MEP cytidylyltransferase; MCTEscherichia coli K-12
Oxidoreductase, putativeBrucella abortus 2308

Compounds (26)

CompoundDescription
diphosphoric acid
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
Thiamine PyrophosphateThe coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
iodoacetamideAn alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
isopentenyl pyrophosphatesubstrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
Edetic AcidA chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Cytidine MonophosphateCytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
Cytidine TriphosphateCytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.
4-hydroxy-3-methylbut-2-enyl pyrophosphatestructure in first source
2-C-methyl-D-erythritol 2,4-cyclodiphosphate
2-C-methylerythritol 4-phosphatestructure in first source
1-deoxy-D-xylulose 5-phosphate
4-diphosphocytidyl-2-c-methylerythritolstructure in first source
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
methylacetylphosphonateinhibitor of pyruvate dehydrogenase complex, don't confuse with methyl acetylphosphonate