Page last updated: 2024-10-06

cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)

Proteins (14)

ProteinSynonymsTaxonomy
Uroporphyrinogen-III C-methyltransferaseUrogen III methylase; EC 2.1.1.107; S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase; SUMT; Uroporphyrinogen III methylase; UROMSinorhizobium sp.
Precorrin-2 C(20)-methyltransferaseEC 2.1.1.130; S-adenosyl-L-methionine--precorrin-2 methyltransferase; SP2MTSinorhizobium sp.
Precorrin-4 C(11)-methyltransferaseEC 2.1.1.133; Precorrin-3 methylaseSinorhizobium sp.
Precorrin-3B synthaseEC 1.14.13.83Sinorhizobium sp.
Precorrin-8X methylmutaseEC 5.4.99.61; HBA synthase; Precorrin isomeraseSinorhizobium sp.
Precorrin-6A synthase [deacetylating]EC 2.1.1.152Sinorhizobium sp.
Precorrin-3B C(17)-methyltransferasePrecorrin-3 methylase; Precorrin-3 methyltransferase; EC 2.1.1.131Sinorhizobium sp.
Precorrin-6Y C(5,15)-methyltransferase [decarboxylating]Precorrin-6 methyltransferase; Precorrin-6Y methylase; EC 2.1.1.132Sinorhizobium sp.
Hydrogenobyrinate a,c-diamide synthaseEC 6.3.5.9; Hydrogenobyrinic acid a,c-diamide synthaseSinorhizobium sp.
Precorrin-6A reductaseEC 1.3.1.54; Precorrin-6X reductaseSinorhizobium sp.
Aerobic cobaltochelatase subunit CobNEC 6.6.1.2; Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobNSinorhizobium sp.
Aerobic cobaltochelatase subunit CobSEC 6.6.1.2; Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobSSinorhizobium sp.
Aerobic cobaltochelatase subunit CobTEC 6.6.1.2; Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobTSinorhizobium sp.
FAD_binding_2 domain-containing proteinRhodobacter capsulatus

Compounds (28)

CompoundDescription
diphosphoric acid
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
NADH
CopperA heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
NickelA trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Adenylyl Imidodiphosphate5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial ATPase and also inhibits ATP-dependent reactions of oxidative phosphorylation.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
ethylmaleimideA sulfhydryl reagent that is widely used in experimental biochemical studies.
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
EthacridineA topically applied anti-infective agent.
15,23-dihydrosirohydrochlorinstructure given in first source
precorrin 8xproposed structure given in first source
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)