Page last updated: 2024-10-06

cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion)

Proteins (17)

ProteinSynonymsTaxonomy
Precorrin-2 dehydrogenaseEC 1.3.1.76Priestia megaterium
Cobalt-precorrin-2 C(20)-methyltransferaseEC 2.1.1.151; S-adenosyl-L-methionine--cobalt-precorrin-2 methyltransferaseSalmonella enterica subsp. enterica serovar Typhimurium str. LT2
Cobalt-precorrin-5B C(1)-methyltransferaseEC 2.1.1.195; Cobalt-precorrin-6A synthaseSalmonella enterica subsp. enterica serovar Typhimurium str. LT2
Cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)EC 2.1.1.196Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Sirohydrochlorin cobaltochelataseEC 4.99.1.3; CbiXLPriestia megaterium
Sirohydrochlorin cobaltochelataseEC 4.99.1.3Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Cobalt-factor III methyltransferaseEC 2.1.1.272; Cobalt-precorrin-3 methylasePriestia megaterium
Cobalt-precorrin-6A reductaseEC 1.3.1.106Priestia megaterium
Cobalt-precorrin-8 methylmutaseEC 5.4.99.60; Cobalt-precorrin isomerasePriestia megaterium
Cobalt-precorrin-4 C(11)-methyltransferaseEC 2.1.1.271; Cobalt-precorrin-3 methylaseSalmonella enterica subsp. enterica serovar Typhimurium str. LT2
Cobalt-precorrin-7 C(5)-methyltransferaseEC 2.1.1.289; Cobalt-precorrin-6Y C(5)-methyltransferase; Cobalt-precorrin-6 methyltransferase; Cobalt-precorrin-6Y methylaseSalmonella enterica subsp. enterica serovar Typhimurium str. LT2
Cobyrinate a,c-diamide synthaseEC 6.3.5.11; Cobyrinic acid a,c-diamide synthetaseSalmonella enterica subsp. enterica serovar Typhimurium str. LT2
Probable cobalt-factor III C(17)-methyltransferaseEC 2.1.1.-; Cobalt-precorrin-3 methyltransferase; Cobalt-precorrin-3 methylaseSalmonella enterica subsp. enterica serovar Typhimurium str. LT2
Cobalt-precorrin-8 methylmutaseEC 5.4.99.60; Cobalt-precorrin isomeraseSalmonella enterica subsp. enterica serovar Typhimurium str. LT2
Cobalt-precorrin-5A hydrolaseEC 3.7.1.12Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Siroheme synthaseSalmonella enterica subsp. enterica serovar Typhimurium str. LT2
Cobalt-precorrin-6A reductaseEC 1.3.1.106Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Compounds (17)

CompoundDescription
hydronium ion
CobaltA trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
NADH
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
cobalt-precorrin 5Astructure in first source
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
acetaldehydeA colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
EthacridineA topically applied anti-infective agent.
sirohydrochlorinchromophore of desulfoviridin; structure
15,23-dihydrosirohydrochlorinstructure given in first source