Page last updated: 2024-10-06

biosynthesis of prostaglandins

Proteins (11)

ProteinSynonymsTaxonomy
15-hydroxyprostaglandin dehydrogenase [NAD(+)]15-PGDH; EC 1.1.1.141; Prostaglandin dehydrogenase 1Mus musculus (house mouse)
Prostaglandin G/H synthase 2EC 1.14.99.1; Cyclooxygenase-2; COX-2; Glucocorticoid-regulated inflammatory cyclooxygenase; Gripghs; Macrophage activation-associated marker protein P71/73; PES-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide syMus musculus (house mouse)
Prostaglandin E synthase 2EC 5.3.99.3; GATE-binding factor 1; GBF-1; Microsomal prostaglandin E synthase 2; mPGES-2Mus musculus (house mouse)
Prostaglandin G/H synthase 1EC 1.14.99.1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1Mus musculus (house mouse)
Hematopoietic prostaglandin D synthaseH-PGDS; EC 5.3.99.2; GST class-sigma; Glutathione S-transferase; 2.5.1.18; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomeraseMus musculus (house mouse)
Prostacyclin synthaseEC 5.3.99.4; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152; Prostaglandin I2 synthaseMus musculus (house mouse)
Prostaglandin E synthasemPGES-1; EC 5.3.99.3; Glutathione peroxidase PTGES; 1.11.1.-; Glutathione transferase PTGES; 2.5.1.18; Microsomal prostaglandin E synthase 1Mus musculus (house mouse)
Prostaglandin-H2 D-isomeraseEC 5.3.99.2; Glutathione-independent PGD synthase; Lipocalin-type prostaglandin-D synthase; Prostaglandin-D2 synthase; L-PGDS; PGD2 synthase; PGDS2Mus musculus (house mouse)
Thromboxane-A synthaseTS; TXA synthase; TXS; EC 5.3.99.5; Cytochrome P450 5A1; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152Mus musculus (house mouse)
Estradiol 17 beta-dehydrogenase 5EC 1.1.1.-; 17-beta-HSD 5Mus musculus (house mouse)
Prostaglandin E synthase 3EC 5.3.99.3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Sid 3177; Telomerase-binding protein p23Mus musculus (house mouse)

Compounds (8)

CompoundDescription
hydronium ion
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
DinoprostoneThe most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
Penicillin VA broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
Thromboxane A2An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).