Page last updated: 2024-10-06

androstenedione degradation

Proteins (33)

ProteinSynonymsTaxonomy
4-hydroxy-2-oxovalerate aldolase 3HOA 3; EC 4.1.3.39; 4-hydroxy-2-keto-pentanoic acid aldolase 3; 4-hydroxy-2-oxopentanoate aldolase 3Rhodococcus jostii RHA1
4-hydroxy-2-oxovalerate aldolase 2HOA 2; EC 4.1.3.39; 4-hydroxy-2-keto-pentanoic acid aldolase 2; 4-hydroxy-2-oxopentanoate aldolase 2Comamonas testosteroni
Acetaldehyde dehydrogenase 3EC 1.2.1.10; Acetaldehyde dehydrogenase [acetylating] 3Rhodococcus jostii RHA1
Acetaldehyde dehydrogenase 1EC 1.2.1.10; Acetaldehyde dehydrogenase [acetylating] 1Comamonas testosteroni
3-oxosteroid 1-dehydrogenaseEC 1.3.99.4; 3-keto-Delta(4)-steroid Delta(1)-dehydrogenase; KSDD; 3-oxo-Delta(4)-steroid 1-dehydrogenase; KSTDMycobacterium tuberculosis H37Rv
(7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA hydrolaseHIEC-CoA hydrolase; EC 4.1.99.-Mycobacterium tuberculosis H37Rv
Propanal dehydrogenase (CoA-propanoylating)EC 1.2.1.87; Acetaldehyde dehydrogenase; 1.2.1.10; Acetaldehyde dehydrogenase [acetylating]Mycobacterium tuberculosis H37Rv
3-ketosteroid-9-alpha-monooxygenase, oxygenase component3-ketosteroid-9-alpha-hydroxylase, oxygenase component; KSH; Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase; 1.14.15.30; Rieske-type oxygenase; RORhodococcus rhodochrous
3-ketosteroid-9-alpha-monooxygenase, oxygenase component3-ketosteroid-9-alpha-hydroxylase, oxygenase component; KSH; Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase; 1.14.15.30; Rieske-type oxygenase; ROMycobacterium tuberculosis H37Rv
2-hydroxyhexa-2,4-dienoate hydrataseEC 4.2.1.132Comamonas testosteroni
Steroid 3-ketoacyl-CoA thiolase FadA6EC 2.3.1.16; Acetyl-CoA acetyltransferase FadA6Mycobacterium tuberculosis H37Rv
Probable acyl-CoA dehydrogenase FadE30Mycobacterium tuberculosis H37Rv
(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA reductaseEC 1.1.1.-Mycobacterium tuberculosis H37Rv
Possible oxidoreductaseMycobacterium tuberculosis H37Rv
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligaseHIP:CoA ligase; EC 6.2.1.41Mycobacterium tuberculosis H37Rv
Flavin-dependent monooxygenase, oxygenase subunit HsaAEC 1.14.14.12; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4-hydroxylase, oxygenase subunit; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenaseMycobacterium tuberculosis H37Rv
4-hydroxy-2-oxohexanoate aldolaseEC 4.1.3.43; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; 4-hydroxy-2-oxovalerate aldolase; HOA; 4.1.3.39Mycobacterium tuberculosis H37Rv
Putative CoA-transferase subunit beta Rv3552EC 2.8.3.-Mycobacterium tuberculosis H37Rv
Putative CoA-transferase subunit alpha Rv3551EC 2.8.3.-Mycobacterium tuberculosis H37Rv
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligaseHIP:CoA ligase; EC 6.2.1.41Rhodococcus jostii RHA1
Flavin-dependent monooxygenase, oxygenase subunit HsaAEC 1.14.14.12; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4-hydroxylase, oxygenase subunit; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenaseRhodococcus jostii RHA1
Iron-dependent extradiol dioxygenaseEC 1.13.11.25Rhodococcus jostii RHA1
Probable acyl-CoA dehydrogenase FadE32Mycobacterium tuberculosis H37Rv
3-ketosteroid-9-alpha-hydroxylase reductase Comamonas testosteroni
Probable hydrataseMycobacterium tuberculosis H37Rv
3-ketosteroid-delta1-dehydrogenase Comamonas testosteroni
2-hydroxypentadienoate hydrataseRhodococcus jostii RHA1
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolaseEC 3.7.1.17; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; 3.7.1.8; Meta-cleavage product hydrolase; MCP hydrolaseMycobacterium tuberculosis H37Rv
Iron-dependent extradiol dioxygenaseEC 1.13.11.25Mycobacterium tuberculosis H37Rv
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolaseEC 3.7.1.17; Meta-cleavage product hydrolase; MCP hydrolaseRhodococcus jostii RHA1
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase Comamonas testosteroni
Iron-dependent extradiol dioxygenase Comamonas testosteroni
3-ketosteroid dehydrogenase Rhodococcus erythropolis

Compounds (26)

CompoundDescription
diphosphoric acid
hydronium ion
NADH
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
ManganeseA trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Flavin MononucleotideA coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
succinyl-coenzyme A
dihydrotestosteroneA potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
1,10-phenanthrolineRN given refers to parent cpd; inhibits Zn-dependent metalloproteinases
1,4-androstadiene-3,17-dionestructure
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
propionaldehydemay cause respiratory irritation; RN given refers to parent cpd; structure
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Coenzyme A
flavin mononucleotide hydroquinonestructure in first source
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
propionyl-coenzyme ARN given refers to parent cpd
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
androstenedioneA delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.