Page last updated: 2024-10-06
androstenedione degradation
Proteins (33)
| Protein | Synonyms | Taxonomy |
|---|---|---|
| 4-hydroxy-2-oxovalerate aldolase 3 | HOA 3; EC 4.1.3.39; 4-hydroxy-2-keto-pentanoic acid aldolase 3; 4-hydroxy-2-oxopentanoate aldolase 3 | Rhodococcus jostii RHA1 |
| 4-hydroxy-2-oxovalerate aldolase 2 | HOA 2; EC 4.1.3.39; 4-hydroxy-2-keto-pentanoic acid aldolase 2; 4-hydroxy-2-oxopentanoate aldolase 2 | Comamonas testosteroni |
| Acetaldehyde dehydrogenase 3 | EC 1.2.1.10; Acetaldehyde dehydrogenase [acetylating] 3 | Rhodococcus jostii RHA1 |
| Acetaldehyde dehydrogenase 1 | EC 1.2.1.10; Acetaldehyde dehydrogenase [acetylating] 1 | Comamonas testosteroni |
| 3-oxosteroid 1-dehydrogenase | EC 1.3.99.4; 3-keto-Delta(4)-steroid Delta(1)-dehydrogenase; KSDD; 3-oxo-Delta(4)-steroid 1-dehydrogenase; KSTD | Mycobacterium tuberculosis H37Rv |
| (7aS)-7a-methyl-1,5-dioxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA hydrolase | HIEC-CoA hydrolase; EC 4.1.99.- | Mycobacterium tuberculosis H37Rv |
| Propanal dehydrogenase (CoA-propanoylating) | EC 1.2.1.87; Acetaldehyde dehydrogenase; 1.2.1.10; Acetaldehyde dehydrogenase [acetylating] | Mycobacterium tuberculosis H37Rv |
| 3-ketosteroid-9-alpha-monooxygenase, oxygenase component | 3-ketosteroid-9-alpha-hydroxylase, oxygenase component; KSH; Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase; 1.14.15.30; Rieske-type oxygenase; RO | Rhodococcus rhodochrous |
| 3-ketosteroid-9-alpha-monooxygenase, oxygenase component | 3-ketosteroid-9-alpha-hydroxylase, oxygenase component; KSH; Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase; 1.14.15.30; Rieske-type oxygenase; RO | Mycobacterium tuberculosis H37Rv |
| 2-hydroxyhexa-2,4-dienoate hydratase | EC 4.2.1.132 | Comamonas testosteroni |
| Steroid 3-ketoacyl-CoA thiolase FadA6 | EC 2.3.1.16; Acetyl-CoA acetyltransferase FadA6 | Mycobacterium tuberculosis H37Rv |
| Probable acyl-CoA dehydrogenase FadE30 | Mycobacterium tuberculosis H37Rv | |
| (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-2,3,5,6,7,7a-hexahydro-1H-indene-carboxyl-CoA reductase | EC 1.1.1.- | Mycobacterium tuberculosis H37Rv |
| Possible oxidoreductase | Mycobacterium tuberculosis H37Rv | |
| 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase | HIP:CoA ligase; EC 6.2.1.41 | Mycobacterium tuberculosis H37Rv |
| Flavin-dependent monooxygenase, oxygenase subunit HsaA | EC 1.14.14.12; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4-hydroxylase, oxygenase subunit; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase | Mycobacterium tuberculosis H37Rv |
| 4-hydroxy-2-oxohexanoate aldolase | EC 4.1.3.43; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxopentanoate aldolase; 4-hydroxy-2-oxovalerate aldolase; HOA; 4.1.3.39 | Mycobacterium tuberculosis H37Rv |
| Putative CoA-transferase subunit beta Rv3552 | EC 2.8.3.- | Mycobacterium tuberculosis H37Rv |
| Putative CoA-transferase subunit alpha Rv3551 | EC 2.8.3.- | Mycobacterium tuberculosis H37Rv |
| 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase | HIP:CoA ligase; EC 6.2.1.41 | Rhodococcus jostii RHA1 |
| Flavin-dependent monooxygenase, oxygenase subunit HsaA | EC 1.14.14.12; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4-hydroxylase, oxygenase subunit; 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase | Rhodococcus jostii RHA1 |
| Iron-dependent extradiol dioxygenase | EC 1.13.11.25 | Rhodococcus jostii RHA1 |
| Probable acyl-CoA dehydrogenase FadE32 | Mycobacterium tuberculosis H37Rv | |
| 3-ketosteroid-9-alpha-hydroxylase reductase | Comamonas testosteroni | |
| Probable hydratase | Mycobacterium tuberculosis H37Rv | |
| 3-ketosteroid-delta1-dehydrogenase | Comamonas testosteroni | |
| 2-hydroxypentadienoate hydratase | Rhodococcus jostii RHA1 | |
| 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | EC 3.7.1.17; 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; HOPDA hydrolase; 3.7.1.8; Meta-cleavage product hydrolase; MCP hydrolase | Mycobacterium tuberculosis H37Rv |
| Iron-dependent extradiol dioxygenase | EC 1.13.11.25 | Mycobacterium tuberculosis H37Rv |
| 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | EC 3.7.1.17; Meta-cleavage product hydrolase; MCP hydrolase | Rhodococcus jostii RHA1 |
| 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | Comamonas testosteroni | |
| Iron-dependent extradiol dioxygenase | Comamonas testosteroni | |
| 3-ketosteroid dehydrogenase | Rhodococcus erythropolis |
Compounds (26)
| Compound | Description |
|---|---|
| diphosphoric acid | |
| hydronium ion | |
| NADH | |
| iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Manganese | A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035) |
| Zinc | A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
| Flavin Mononucleotide | A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| succinyl-coenzyme A | |
| dihydrotestosterone | A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. |
| Pyruvic Acid | An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed) |
| 1,10-phenanthroline | RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases |
| 1,4-androstadiene-3,17-dione | structure |
| adenosine monophosphate | Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| propionaldehyde | may cause respiratory irritation; RN given refers to parent cpd; structure |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| Coenzyme A | |
| flavin mononucleotide hydroquinone | structure in first source |
| Acetyl Coenzyme A | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| propionyl-coenzyme A | RN given refers to parent cpd |
| Flavin-Adenine Dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |
| androstenedione | A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL. |