Venlafaxine Metabolism Pathway

Proteins (6)

Protein	Synonyms	Taxonomy
ATP-dependent translocase ABCB1	ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; 7.6.2.2; P-glycoprotein 1; Phospholipid transporter ABCB1; 7.6.2.1	Homo sapiens (human)
Cytochrome P450 3A4	EC 1.14.14.1; 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; 1.14.14.56; Albendazole monooxygenase (sulfoxide-forming); 1.14.14.73; Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cholesterol 25-hydroxylase; Cytochrome P450 3A3; Cytochrome	Homo sapiens (human)
Cytochrome P450 2D6	EC 1.14.14.-; CYPIID6; Cholesterol 25-hydroxylase; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase	Homo sapiens (human)
Sodium-dependent serotonin transporter	SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4	Homo sapiens (human)
Cytochrome P450 2C19	EC 1.14.14.1; (R)-limonene 6-monooxygenase; 1.14.14.53; (S)-limonene 6-monooxygenase; 1.14.14.51; (S)-limonene 7-monooxygenase; 1.14.14.52; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Fenbendazole monooxygenase (4'-hydroxylating); 1.14.	Homo sapiens (human)
Sodium-dependent noradrenaline transporter	Norepinephrine transporter; NET; Solute carrier family 6 member 2	Homo sapiens (human)

Compound	Description
desvenlafaxine
NADH
venlafaxine
formaldehyde	A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
Water	A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
n,o-didesmethylvenlafaxine	structure in first source
n-desmethylvenlafaxine	structure in first source
NAD	A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)