Page last updated: 2024-10-06

Valproic Acid Metabolism Pathway

Proteins (11)

ProteinSynonymsTaxonomy
Trifunctional enzyme subunit alpha, mitochondrial78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; 2.3.1.-; TP-alphaHomo sapiens (human)
3-hydroxyacyl-CoA dehydrogenase type-2 EC 1.1.1.35; 17-beta-estradiol 17-dehydrogenase; 1.1.1.62; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; MHBD; 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); 1.1.1.239; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 1.1.1.178; 3-hydroxyacyl-CoA dehHomo sapiens (human)
Cytochrome P450 2C9 EC 1.14.14.1; (R)-limonene 6-monooxygenase; 1.14.14.53; (S)-limonene 6-monooxygenase; 1.14.14.51; (S)-limonene 7-monooxygenase; 1.14.14.52; CYPIIC9; Cholesterol 25-hydroxylase; Cytochrome P-450MP; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P45Homo sapiens (human)
Cytochrome P450 2B6EC 1.14.13.-; 1,4-cineole 2-exo-monooxygenase; CYPIIB6; Cytochrome P450 IIB1Homo sapiens (human)
Trifunctional enzyme subunit beta, mitochondrialTP-betaHomo sapiens (human)
Cytochrome P450 2A6EC 1.14.13.-; 1,4-cineole 2-exo-monooxygenase; CYPIIA6; Coumarin 7-hydroxylase; Cytochrome P450 IIA3; Cytochrome P450(I)Homo sapiens (human)
UDP-glucuronosyltransferase 1A3UGT1A3; EC 2.4.1.17; UDP-glucuronosyltransferase 1-3; UDPGT 1-3; UGT1*3; UGT1-03; UGT1.3; UDP-glucuronosyltransferase 1-C; UGT-1C; UGT1C; UDP-glucuronosyltransferase 1A isoform 3Homo sapiens (human)
Peroxisomal bifunctional enzymePBE; PBFE; L-bifunctional protein; LBP; Multifunctional enzyme 1; MFE1Homo sapiens (human)
Isovaleryl-CoA dehydrogenase, mitochondrial IVD; EC 1.3.8.4; Butyryl-CoA dehydrogenase; 1.3.8.1Homo sapiens (human)
Acyl-coenzyme A synthetase ACSM1, mitochondrialEC 6.2.1.2; Acyl-CoA synthetase medium-chain family member 1; Benzoate--CoA ligase; 6.2.1.25; Butyrate--CoA ligase 1; Butyryl-coenzyme A synthetase 1; Lipoate-activating enzyme; Middle-chain acyl-CoA synthetase 1; Xenobiotic/medium-chain fatty acid-CoA liHomo sapiens (human)
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialSBCAD; EC 1.3.8.5; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenaseHomo sapiens (human)

Compounds (21)

CompoundDescription
hydronium ion
valproic acidA fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
NADH
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Coenzyme A
2-propyl-4-pentenoic acidputative toxic metabolite of valproic acid
5-hydroxyvalproate
uridine diphosphate glucuronic acidA nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones.
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
trans-2-en-valproate
2-propyl-2,4-pentadienoic acidtoxic metabolite of valproic acid; RN given refers to cpd without isomeric designation
4-hydroxyvalproateRN given refers to compound with no isomeric designation
2-n-propyl-3-oxopentanoic acidstructure given in first source
delta(3) valproic acidstructure in first source
creolinfrom refined coal tar oils
pyrophosphate
valproic acid glucuronidemajor metabolite of valproic acid