Pathways > Uricosurics Pathway, Pharmacodynamics
Page last updated: 2024-10-06
Uricosurics Pathway, Pharmacodynamics
Proteins (9)
| Protein | Synonyms | Taxonomy |
|---|
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | EC 7.6.2.2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter | Homo sapiens (human) |
| Multidrug resistance-associated protein 4 | ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B | Homo sapiens (human) |
| Solute carrier family 22 member 12 | Organic anion transporter 4-like protein; Renal-specific transporter; RST; Urate anion exchanger 1 | Homo sapiens (human) |
| Solute carrier family 2, facilitated glucose transporter member 9 | Glucose transporter type 9; GLUT-9; Urate transporter | Homo sapiens (human) |
| Solute carrier family 22 member 8 | Organic anion transporter 3; hOAT3 | Homo sapiens (human) |
| Solute carrier family 22 member 11 | Organic anion transporter 4 | Homo sapiens (human) |
| Sodium-dependent phosphate transport protein 1 | Na(+)/PI cotransporter 1; Na/Pi-4; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; Sodium/phosphate cotransporter 1; Solute carrier family 17 member 1 | Homo sapiens (human) |
| Solute carrier family 22 member 13 | Organic cation transporter-like 3; ORCTL-3 | Homo sapiens (human) |
| cDNA FLJ31202 fis, clone KIDNE2003188, highly similar to Homo sapiens solute carrier family 22 | | Homo sapiens (human) |
Compounds (3)
| Compound | Description |
|---|
| tranilast | antiallergic drug; potent inhibitor of homologous passive cutaneous anaphylaxis |
| uric acid | An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN. |
| benzbromarone | Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout. |