Page last updated: 2024-10-06

Uricosurics Pathway, Pharmacodynamics

Proteins (9)

ProteinSynonymsTaxonomy
Broad substrate specificity ATP-binding cassette transporter ABCG2EC 7.6.2.2; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporterHomo sapiens (human)
Multidrug resistance-associated protein 4ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-BHomo sapiens (human)
Solute carrier family 22 member 12Organic anion transporter 4-like protein; Renal-specific transporter; RST; Urate anion exchanger 1Homo sapiens (human)
Solute carrier family 2, facilitated glucose transporter member 9Glucose transporter type 9; GLUT-9; Urate transporterHomo sapiens (human)
Solute carrier family 22 member 8Organic anion transporter 3; hOAT3Homo sapiens (human)
Solute carrier family 22 member 11Organic anion transporter 4Homo sapiens (human)
Sodium-dependent phosphate transport protein 1Na(+)/PI cotransporter 1; Na/Pi-4; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; Sodium/phosphate cotransporter 1; Solute carrier family 17 member 1Homo sapiens (human)
Solute carrier family 22 member 13Organic cation transporter-like 3; ORCTL-3Homo sapiens (human)
cDNA FLJ31202 fis, clone KIDNE2003188, highly similar to Homo sapiens solute carrier family 22 Homo sapiens (human)

Compounds (3)

CompoundDescription
tranilastantiallergic drug; potent inhibitor of homologous passive cutaneous anaphylaxis
uric acidAn oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
benzbromaroneUricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.