Page last updated: 2024-10-06

Uptake and function of anthrax toxins

Proteins (10)

ProteinSynonymsTaxonomy
Dual specificity mitogen-activated protein kinase kinase 2MAP kinase kinase 2; MAPKK 2; EC 2.7.12.2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2Homo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 1MAP kinase kinase 1; MAPKK 1; MKK1; EC 2.7.12.2; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1Homo sapiens (human)
FurinEC 3.4.21.75; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACEHomo sapiens (human)
Lethal factorLF; EC 3.4.24.83; Anthrax lethal toxin endopeptidase componentBacillus anthracis
Calmodulin-sensitive adenylate cyclaseEC 4.6.1.1; ATP pyrophosphate-lyase; Adenylyl cyclase; Anthrax edema toxin adenylate cyclase component; Edema factor; EFBacillus anthracis
Dual specificity mitogen-activated protein kinase kinase 7MAP kinase kinase 7; MAPKK 7; EC 2.7.12.2; JNK-activating kinase 2; MAPK/ERK kinase 7; MEK 7; Stress-activated protein kinase kinase 4; SAPK kinase 4; SAPKK-4; SAPKK4; c-Jun N-terminal kinase kinase 2; JNK kinase 2; JNKK 2Homo sapiens (human)
Calmodulin-1Homo sapiens (human)
Protective antigenPA; Anthrax toxins translocating protein; PA-83; PA83Bacillus anthracis
Dual specificity mitogen-activated protein kinase kinase 4MAP kinase kinase 4; MAPKK 4; EC 2.7.12.2; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKKHomo sapiens (human)
Programmed cell death 6-interacting proteinPDCD6-interacting protein; ALG-2-interacting protein 1; ALG-2-interacting protein X; Hp95Homo sapiens (human)

Compounds (5)

CompoundDescription
hydronium ion
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
cyclic ampAn adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.