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Tryptophan Metabolism II

Proteins (6)

ProteinSynonymsTaxonomy
TryptophanaseEC 4.1.99.1; L-tryptophan indole-lyase; TNaseEscherichia coli K-12
Tryptophan synthase alpha chainEC 4.2.1.20Escherichia coli K-12
Tryptophan synthase beta chainEC 4.2.1.20Escherichia coli K-12
Anthranilate synthase component 1AS; ASI; EC 4.1.3.27Escherichia coli K-12
Bifunctional protein TrpGDEscherichia coli K-12
Tryptophan biosynthesis protein TrpCFEscherichia coli K-12

Compounds (20)

CompoundDescription
hydronium ion
pyruvic acidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
NADH
glutamineA non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
tryptophanAn essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
phosphoribosyl pyrophosphateThe key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
indoleglycerol phosphateinducer of tryptophan synthase
Coenzyme A
chorismic acidA cyclohexadiene carboxylic acid derived from SHIKIMIC ACID and a precursor for the biosynthesis of UBIQUINONE and the AROMATIC AMINO ACIDS.
dehydroalanine
anthranilic acidRN given refers to parent cpd; structure in Negwer, 5th ed, #565
NADA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
serineA non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
Glyceraldehyde 3-PhosphateAn aldotriose which is an important intermediate in glycolysis and in tryptophan biosynthesis.
indoleRN given refers to parent cpd; structure in Merck Index, 9th ed, #4840
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
pyrophosphate