Page last updated: 2024-10-06

Tolerance by Mtb to nitric oxide produced by macrophages

Proteins (11)

ProteinSynonymsTaxonomy
ThioredoxinTrx; MPT46Mycobacterium tuberculosis H37Rv
Thiol peroxidaseTpx; EC 1.11.1.24; Peroxiredoxin tpx; Prx; Thioredoxin peroxidase; Thioredoxin-dependent peroxiredoxinMycobacterium tuberculosis H37Rv
Alkyl hydroperoxide reductase EEC 1.11.1.29; Mycoredoxin-dependent peroxiredoxin; Peroxiredoxin AhpE; Prx; Thioredoxin peroxidase; TPxMycobacterium tuberculosis H37Rv
Gamma-glutamyltransferase Mycobacterium tuberculosis CDC1551
S-nitrosomycothiol reductase MscRMycobacterium tuberculosis H37Rv
Group 1 truncated hemoglobin GlbNTruncated hemoglobin; trHbN; Hemoglobin-like protein HbNMycobacterium tuberculosis H37Rv
Putative peptide transport permease protein Rv1283cMycobacterium tuberculosis H37Rv
Putative peptide transport permease protein Rv1282cMycobacterium tuberculosis H37Rv
Uncharacterized protein Rv1280cMycobacterium tuberculosis H37Rv
Uncharacterized ABC transporter ATP-binding protein Rv1281cMycobacterium tuberculosis H37Rv
Alkyl hydroperoxide reductase CMtAhpC; EC 1.11.1.28; Peroxiredoxin; Thioredoxin peroxidaseMycobacterium tuberculosis H37Rv

Compounds (17)

CompoundDescription
hydronium ion
GlutathioneA tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Nitric OxideA free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
NADH
ammonium hydroxideThe hydroxy salt of ammonium ion. It is formed when AMMONIA reacts with water molecules in solution.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
nitrosonium iona nitric oxide congener
nitratesInorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
nitritesSalts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
s-nitrosoglutathioneA sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
mycothiola glyco-inositol-cysteine found in MYCOBACTERIUM BOVIS which conjugates exogenous compounds for detoxication; it is a microbe counterpart to eucaryotic GLUTATHIONE; acted on by mycothiol disulfide reductase and mycothiol S-conjugate amidase and MDF dehydrogenase;
s-nitrosocysteinylglycinenitric oxide adduct; found in the rat brain
Peroxynitrite
hemeThe color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.