Page last updated: 2024-10-06
Threonine Biosynthesis
Proteins (11)
| Protein | Synonyms | Taxonomy |
|---|
| Bifunctional aspartokinase/homoserine dehydrogenase 1 | Aspartokinase I/homoserine dehydrogenase I; AKI-HDI | Escherichia coli K-12 |
| Homoserine kinase | HK; HSK; EC 2.7.1.39 | Escherichia coli K-12 |
| Aspartate aminotransferase | AspAT; EC 2.6.1.1; Transaminase A | Escherichia coli K-12 |
| Lysine-sensitive aspartokinase 3 | EC 2.7.2.4; Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III | Escherichia coli K-12 |
| L-threonine 3-dehydrogenase | TDH; EC 1.1.1.103; L-threonine dehydrogenase | Escherichia coli K-12 |
| Threonine synthase | TS; EC 4.2.3.1 | Escherichia coli K-12 |
| 2-amino-3-ketobutyrate coenzyme A ligase | AKB ligase; EC 2.3.1.29; Glycine acetyltransferase | Escherichia coli K-12 |
| Bifunctional aspartokinase/homoserine dehydrogenase 2 | Aspartokinase II/homoserine dehydrogenase II; AKII-HDII | Escherichia coli K-12 |
| Aspartate-semialdehyde dehydrogenase | ASA dehydrogenase; ASADH; EC 1.2.1.11; Aspartate-beta-semialdehyde dehydrogenase | Escherichia coli K-12 |
| Stress response kinase A | EC 2.7.11.1; Serine/threonine protein kinase YihE; Serine/threonine-protein kinase SrkA | Escherichia coli K-12 |
| Threonine/serine transporter TdcC | H(+)/threonine-serine symporter | Escherichia coli str. K-12 substr. DH10B |
Compounds (19)
| Compound | Description |
|---|
| hydronium ion | |
| Orthophosphate | |
| glutamic acid | A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. |
| NADH | |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| threonine | An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Coenzyme A | |
| aminomalonic acid | aspartase-ammonia ligase inhibitor |
| homoserine | |
| o-phosphohomoserine | RN given refers to L-isomer |
| aspartic semialdehyde | RN given refers to cpd without isomeric designation |
| 2-amino-3-ketobutyrate | unstable intermediate in threonine dehydrogenase-initiated pathway for threonine utilization; structure given in first source |
| alpha-ketoglutaric acid | |
| NAD | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| oxaloacetic acid | A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE. |
| acetyl coenzyme a | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| creolin | from refined coal tar oils |