Page last updated: 2024-10-06

Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

Proteins (24)

ProteinSynonymsTaxonomy
Equilibrative nucleoside transporter 236 kDa nucleolar protein HNP36; Delayed-early response protein 12; Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter; Equilibrative NBMPR-insensitive nucleoside transporter; Hydrophobic nucleolar protein, 36 kDa; NucleosiHomo sapiens (human)
Multidrug resistance-associated protein 5ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP; pABC11Homo sapiens (human)
Multidrug resistance-associated protein 4ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-BHomo sapiens (human)
Hypoxanthine-guanine phosphoribosyltransferaseHGPRT; HGPRTase; EC 2.4.2.8Homo sapiens (human)
Xanthine dehydrogenase/oxidaseHomo sapiens (human)
Equilibrative nucleoside transporter 1Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1Homo sapiens (human)
Sodium/nucleoside cotransporter 2Concentrative nucleoside transporter 2; CNT 2; hCNT2; Na(+)/nucleoside cotransporter 2; Sodium-coupled nucleoside transporter 2; Sodium/purine nucleoside co-transporter; SPNT; Solute carrier family 28 member 2Homo sapiens (human)
Nucleoside diphosphate kinase ANDK A; NDP kinase A; EC 2.7.4.6; Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; NM23-H1; Tumor metastatic process-associated proteinHomo sapiens (human)
Ribonucleoside-diphosphate reductase large subunitEC 1.17.4.1; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunitHomo sapiens (human)
Ribonucleoside-diphosphate reductase subunit M2EC 1.17.4.1; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunitHomo sapiens (human)
Adenosine kinaseAK; EC 2.7.1.20; Adenosine 5'-phosphotransferaseHomo sapiens (human)
Guanine deaminaseGuanase; Guanine aminase; EC 3.5.4.3; Guanine aminohydrolase; GAH; p51-nedasinHomo sapiens (human)
Glutathione S-transferase Mu 1EC 2.5.1.18; GST HB subunit 4; GST class-mu 1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4Homo sapiens (human)
Glutathione S-transferase A1EC 2.5.1.18; 13-hydroperoxyoctadecadienoate peroxidase; 1.11.1.-; Androst-5-ene-3,17-dione isomerase; 5.3.3.-; GST HA subunit 1; GST class-alpha member 1; GST-epsilon; GSTA1-1; GTH1Homo sapiens (human)
Aldehyde oxidaseEC 1.2.3.1; Aldehyde oxidase 1; Azaheterocycle hydroxylase; 1.17.3.-Homo sapiens (human)
Thiopurine S-methyltransferaseEC 2.1.1.67; Thiopurine methyltransferaseHomo sapiens (human)
Ribose-phosphate pyrophosphokinase 1EC 2.7.6.1; PPRibP; Phosphoribosyl pyrophosphate synthase I; PRS-IHomo sapiens (human)
Nucleotide triphosphate diphosphatase NUDT15EC 3.6.1.9; MutT homolog 2; MTH2; Nucleoside diphosphate-linked moiety X motif 15; Nudix motif 15; Nucleoside diphosphate-linked to another moiety X hydrolase 15; Nudix hydrolase 15Homo sapiens (human)
Solute carrier family 28 member 3Concentrative Na(+)-nucleoside cotransporter 3; CNT 3; hCNT3Homo sapiens (human)
Nucleoside diphosphate kinase Homo sapiens (human)
Ras-related C3 botulinum toxin substrate 1 Homo sapiens (human)
Amidophosphoribosyltransferase Homo sapiens (human)
cDNA FLJ75877, highly similar to Homo sapiens 5'-nucleotidase, cytosolic II Homo sapiens (human)
Glutathione transferase Homo sapiens (human)

Compounds (14)

CompoundDescription
phosphoribosyl pyrophosphateThe key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
thioinosineSulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)
2'-deoxy-6-thioguanosine 5'-triphosphate
6-thiouric acidstructure
6-thioguanylic acid
6-thioinosine-5'-triphosphate
6-thioxanthine 5'-monophosphate
6-methylthiopurine
s-adenosylhomocysteine5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.
ribose-5-phosphateRN given refers to cpd without isomeric designation
6-thioxanthinegpt/6-TXenzyme/prodrug pair is a promising alternative to the thymidine kinase gene and ganciclovir combination in the gene therapy of cancer
6-thioguanosine 5'-diphosphate
6-thioguanosine 5'-triphosphate
6-methylthiopurine ribonucleoside-5'-phosphatecauses cyotoxicity