Page last updated: 2024-10-06

Thiamin Diphosphate Biosynthesis

Proteins (10)

ProteinSynonymsTaxonomy
Phosphoribosylglycinamide formyltransferaseEC 2.1.2.2; 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GARTEscherichia coli K-12
Phosphoribosylformylglycinamidine synthaseFGAM synthase; FGAMS; EC 6.3.5.3; Formylglycinamide ribonucleotide amidotransferase; FGAR amidotransferase; FGAR-ATEscherichia coli K-12
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinaseEC 2.7.1.49; EC 2.7.4.7; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinaseEscherichia coli K-12
AmidophosphoribosyltransferaseATase; EC 2.4.2.14; Glutamine phosphoribosylpyrophosphate amidotransferase; GPATaseEscherichia coli K-12
Phosphoribosylformylglycinamidine cyclo-ligaseEC 6.3.3.1; AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetaseEscherichia coli K-12
Thiamine-monophosphate kinaseTMP kinase; Thiamine-phosphate kinase; EC 2.7.4.16Escherichia coli K-12
Phosphoribosylamine--glycine ligaseEC 6.3.4.13; GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetaseEscherichia coli K-12
Phosphomethylpyrimidine synthaseEC 4.1.99.17; Hydroxymethylpyrimidine phosphate synthase; HMP-P synthase; HMP-phosphate synthase; HMPP synthase; Thiamine biosynthesis protein ThiCEscherichia coli K-12
Thiamine-phosphate synthaseTP synthase; TPS; EC 2.5.1.3; Thiamine-phosphate pyrophosphorylase; TMP pyrophosphorylase; TMP-PPaseEscherichia coli K-12
Formate-dependent phosphoribosylglycinamide formyltransferase5'-phosphoribosylglycinamide transformylase 2; Formate-dependent GAR transformylase; 2.1.2.-; GAR transformylase 2; GART 2; Non-folate glycinamide ribonucleotide transformylase; Phosphoribosylglycinamide formyltransferase 2Escherichia coli K-12

Compounds (17)

CompoundDescription
hydronium ion
Orthophosphate
Thiamine PyrophosphateThe coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
carbon monoxideCarbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
glutamineA non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
methionineA sulfur-containing essential L-amino acid that is important in many body functions.
phosphoribosyl pyrophosphateThe key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
phosphoribosyl-N-formylglycineamide
5'-deoxyadenosinemain heading DEOXYADENOSINE refers to the 3' cpd
aminoimidazole ribotide
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
pyrophosphate