Page last updated: 2024-10-06

The retinoid cycle in cones (daylight vision)

Proteins (7)

ProteinSynonymsTaxonomy
Retinaldehyde-binding protein 1Cellular retinaldehyde-binding proteinHomo sapiens (human)
Acyl-CoA wax alcohol acyltransferase 2EC 2.3.1.75; 11-cis-specific retinyl-ester synthase; 11-cis-RE-synthase; Acyl-CoA retinol O-fatty-acyltransferase; ARAT; Retinol O-fatty-acyltransferase; 2.3.1.76; Diacylglycerol O-acyltransferase 2-like protein 4; Diacylglycerol O-acyltransferase candidaHomo sapiens (human)
Long-wave-sensitive opsin 1Red cone photoreceptor pigment; Red-sensitive opsin; ROPHomo sapiens (human)
Retinol-binding protein 3Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding proteinHomo sapiens (human)
Short-wave-sensitive opsin 1Blue cone photoreceptor pigment; Blue-sensitive opsin; BOPHomo sapiens (human)
Short-chain dehydrogenase/reductase 3EC 1.1.1.300; DD83.1; Retinal short-chain dehydrogenase/reductase 1; retSDR1; Retinol dehydrogenase 17; Short chain dehydrogenase/reductase family 16C member 1Homo sapiens (human)
Medium-wave-sensitive opsin 1Green cone photoreceptor pigment; Green-sensitive opsin; GOPHomo sapiens (human)

Compounds (11)

CompoundDescription
hydronium ion
retinol
retinaldehydeA diterpene derived from the carotenoid VITAMIN A which functions as the active component of the visual cycle. It is the prosthetic group of RHODOPSIN (i.e., covalently bonded to ROD OPSIN as 11-cis-retinal). When stimulated by visible light, rhodopsin transforms this cis-isomer of retinal to the trans-isomer (11-trans-retinal). This transformation straightens-out the bend of the retinal molecule and causes a change in the shape of rhodopsin triggering the visual process. A series of energy-requiring enzyme-catalyzed reactions convert the 11-trans-retinal back to the cis-isomer.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
palmitic acidA common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
11-cis-Retinol
11-cis-retinal
Coenzyme A
Palmitoyl Coenzyme AA fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis.