Page last updated: 2024-10-06

The canonical retinoid cycle in rods (twilight vision)

Proteins (14)

ProteinSynonymsTaxonomy
Retinaldehyde-binding protein 1Cellular retinaldehyde-binding proteinHomo sapiens (human)
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase DN-acyl phosphatidylethanolamine phospholipase D; NAPE-PLD; NAPE-hydrolyzing phospholipase D; EC 3.1.4.54Homo sapiens (human)
Retinoid isomerohydrolaseEC 3.1.1.64; All-trans-retinyl-palmitate hydrolase; Lutein isomerase; Meso-zeaxanthin isomerase; 5.3.3.22; Retinal pigment epithelium-specific 65 kDa protein; Retinol isomeraseHomo sapiens (human)
RhodopsinOpsin-2Homo sapiens (human)
TransthyretinATTR; Prealbumin; TBPAHomo sapiens (human)
Retinol-binding protein 4Plasma retinol-binding protein; PRBP; RBPHomo sapiens (human)
Lecithin retinol acyltransferaseEC 2.3.1.135; Phosphatidylcholine--retinol O-acyltransferaseHomo sapiens (human)
Retinol-binding protein 3Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding proteinHomo sapiens (human)
Retinol-binding protein 1Cellular retinol-binding protein; CRBP; Cellular retinol-binding protein I; CRBP-IHomo sapiens (human)
Retinal-specific phospholipid-transporting ATPase ABCA4EC 7.6.2.1; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease proteinHomo sapiens (human)
Unconventional myosin-VIIaHomo sapiens (human)
Cytochrome P450 4V2Docosahexaenoic acid omega-hydroxylase CYP4V2; 1.14.14.79; Long-chain fatty acid omega-monooxygenase; 1.14.14.80Homo sapiens (human)
Retinol dehydrogenase 12EC 1.1.1.300; All-trans and 9-cis retinol dehydrogenase; Short chain dehydrogenase/reductase family 7C member 2Homo sapiens (human)
Receptor for retinol uptake STRA6Retinol-binding protein receptor STRA6; Stimulated by retinoic acid gene 6 protein homologHomo sapiens (human)

Compounds (14)

CompoundDescription
hydronium ion
NADH
Orthophosphate
retinol
retinaldehydeA diterpene derived from the carotenoid VITAMIN A which functions as the active component of the visual cycle. It is the prosthetic group of RHODOPSIN (i.e., covalently bonded to ROD OPSIN as 11-cis-retinal). When stimulated by visible light, rhodopsin transforms this cis-isomer of retinal to the trans-isomer (11-trans-retinal). This transformation straightens-out the bend of the retinal molecule and causes a change in the shape of rhodopsin triggering the visual process. A series of energy-requiring enzyme-catalyzed reactions convert the 11-trans-retinal back to the cis-isomer.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
11-cis-Retinol
11-cis-retinal
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.