Page last updated: 2024-10-06

Terpenoid Backbone Biosynthesis

Proteins (13)

ProteinSynonymsTaxonomy
Dehydrodolichyl diphosphate synthase complex subunit RER2DEDOL-PP synthase; EC 2.5.1.87; Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)Saccharomyces cerevisiae S288C
Dehydrodolichyl diphosphate synthase complex subunit SRT1EC 2.5.1.87; Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)Saccharomyces cerevisiae S288C
Dehydrodolichyl diphosphate synthase complex subunit NUS1EC 2.5.1.87; Nuclear undecaprenyl pyrophosphate synthase 1Saccharomyces cerevisiae S288C
Hydroxymethylglutaryl-CoA synthaseHMG-CoA synthase; EC 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthaseSaccharomyces cerevisiae S288C
Farnesyl pyrophosphate synthaseFPP synthase; FPS; EC 2.5.1.10; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; 2.5.1.1; Farnesyl diphosphate synthase; GeranyltranstransferaseSaccharomyces cerevisiae S288C
Mevalonate kinaseMK; MvK; EC 2.7.1.36; Ergosterol biosynthesis protein 12; Regulation of autonomous replication protein 1Saccharomyces cerevisiae S288C
Isopentenyl-diphosphate Delta-isomeraseEC 5.3.3.2; Isopentenyl pyrophosphate isomerase; IPP isomeraseSaccharomyces cerevisiae S288C
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1HMG-CoA reductase 1; EC 1.1.1.34Saccharomyces cerevisiae S288C
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2HMG-CoA reductase 2; EC 1.1.1.34Saccharomyces cerevisiae S288C
Hexaprenyl pyrophosphate synthase, mitochondrialHPS; EC 2.5.1.-Saccharomyces cerevisiae S288C
Phosphomevalonate kinaseEC 2.7.4.2Saccharomyces cerevisiae S288C
3-ketoacyl-CoA thiolase, peroxisomalEC 2.3.1.16; Acetyl-CoA acyltransferase; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolaseSaccharomyces cerevisiae S288C
Diphosphomevalonate decarboxylaseEC 4.1.1.33; Ergosterol biosynthesis protein 19; Mevalonate pyrophosphate decarboxylase; Mevalonate-5-diphosphate decarboxylase; MDD; MDDaseSaccharomyces cerevisiae S288C

Compounds (17)

CompoundDescription
Orthophosphate
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Coenzyme A
isopentenyl pyrophosphatesubstrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
5-diphosphomevalonic acidRN given refers to ion(1-)
farnesyl pyrophosphatea sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation
geranyl pyrophosphateRN given refers to (E)-isomer
Mevalonic AcidA dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.
phosphomevalonate
acetyl coenzyme aAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
geranylgeranyl pyrophosphateRN given refers to (E,E,E)-isomer
creolinfrom refined coal tar oils
pyrophosphate
3,3-dimethylallyl pyrophosphateisomeric with isopentenyl pyrophosphate