Page last updated: 2024-10-06

TCF dependent signaling in response to WNT

Proteins (104)

ProteinSynonymsTaxonomy
Histone-lysine N-methyltransferase 2DLysine N-methyltransferase 2D; EC 2.1.1.354; ALL1-related protein; Myeloid/lymphoid or mixed-lineage leukemia protein 2Homo sapiens (human)
Phosphatidylinositol 4-phosphate 5-kinase type-1 betaPIP5K1-beta; PtdIns(4)P-5-kinase 1 beta; EC 2.7.1.68; Phosphatidylinositol 4-phosphate 5-kinase type I beta; PIP5KIbeta; Protein STM-7; Type I phosphatidylinositol 4-phosphate 5-kinase betaHomo sapiens (human)
Low-density lipoprotein receptor-related protein 6LRP-6Homo sapiens (human)
E3 ubiquitin-protein ligase RBX1EC 2.3.2.27; EC 2.3.2.32; E3 ubiquitin-protein transferase RBX1; Protein ZYP; RING finger protein 75; RING-box protein 1; Rbx1; Regulator of cullins 1; ROC1Homo sapiens (human)
CXXC-type zinc finger protein 4Inhibition of the Dvl and axin complex proteinHomo sapiens (human)
Proteasome subunit beta type-9EC 3.4.25.1; Low molecular mass protein 2; Macropain chain 7; Multicatalytic endopeptidase complex chain 7; Proteasome chain 7; Proteasome subunit beta-1i; Really interesting new gene 12 proteinHomo sapiens (human)
Casein kinase I isoform epsilonCKI-epsilon; CKIe; EC 2.7.11.1Homo sapiens (human)
Glycogen synthase kinase-3 betaGSK-3 beta; EC 2.7.11.26; Serine/threonine-protein kinase GSK3B; 2.7.11.1Homo sapiens (human)
E3 ubiquitin-protein ligase XIAPEC 2.3.2.27; Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; RING-type E3 ubiquitin transferase XIAP; X-linked inhibitor of apoptosis protein; X-linked IAPHomo sapiens (human)
Histone deacetylase 1HD1; EC 3.5.1.98Homo sapiens (human)
SclerostinHomo sapiens (human)
Beta-catenin-interacting protein 1Inhibitor of beta-catenin and Tcf-4Homo sapiens (human)
Telomerase reverse transcriptaseEC 2.7.7.49; HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2Homo sapiens (human)
Axin-1Axis inhibition protein 1; hAxinHomo sapiens (human)
Proteasome subunit beta type-1Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; Proteasome component C5; Proteasome gamma chainHomo sapiens (human)
Casein kinase I isoform alphaCKI-alpha; EC 2.7.11.1; CK1Homo sapiens (human)
Protein Wnt-3aHomo sapiens (human)
Casein kinase II subunit betaCK II beta; Phosvitin; Protein G5aHomo sapiens (human)
Caveolin-1Homo sapiens (human)
Proteasome activator complex subunit 311S regulator complex subunit gamma; REG-gamma; Activator of multicatalytic protease subunit 3; Ki nuclear autoantigen; Proteasome activator 28 subunit gamma; PA28g; PA28gammaHomo sapiens (human)
Segment polarity protein dishevelled homolog DVL-1Dishevelled-1; DSH homolog 1Homo sapiens (human)
Segment polarity protein dishevelled homolog DVL-2Dishevelled-2; DSH homolog 2Homo sapiens (human)
Exportin-1Exp1; Chromosome region maintenance 1 protein homologHomo sapiens (human)
Proteasome subunit beta type-3Proteasome chain 13; Proteasome component C10-II; Proteasome theta chainHomo sapiens (human)
Axin-2Axin-like protein; Axil; Axis inhibition protein 2; ConductinHomo sapiens (human)
26S proteasome non-ATPase regulatory subunit 1026S proteasome regulatory subunit p28; Gankyrin; p28(GANK)Homo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase 8EC 3.4.19.12; Deubiquitinating enzyme 8; Ubiquitin isopeptidase Y; hUBPy; Ubiquitin thioesterase 8; Ubiquitin-specific-processing protease 8Homo sapiens (human)
C-terminal-binding protein 1CtBP1; EC 1.1.1.-Homo sapiens (human)
Frizzled-5Fz-5; hFz5; FzE5Homo sapiens (human)
E3 ubiquitin-protein ligase SMURF2hSMURF2; EC 2.3.2.26; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2Homo sapiens (human)
Myc proto-oncogene proteinClass E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64Homo sapiens (human)
Adenomatous polyposis coli proteinProtein APC; Deleted in polyposis 2.5Homo sapiens (human)
Proteasome subunit beta type-8EC 3.4.25.1; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; Proteasome component C13; Proteasome subunit beta-5i; Really interesting new gene 10 proteinHomo sapiens (human)
Proteasome subunit beta type-5EC 3.4.25.1; Macropain epsilon chain; Multicatalytic endopeptidase complex epsilon chain; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit MB1; Proteasome subunit XHomo sapiens (human)
Catenin beta-1Beta-cateninHomo sapiens (human)
Proteasome subunit beta type-2Macropain subunit C7-I; Multicatalytic endopeptidase complex subunit C7-I; Proteasome component C7-IHomo sapiens (human)
Histone H4Homo sapiens (human)
Casein kinase I isoform gamma-2CKI-gamma 2; EC 2.7.11.1Homo sapiens (human)
Histone acetyltransferase KAT5EC 2.3.1.48; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting proteinHomo sapiens (human)
Retinoblastoma-binding protein 5RBBP-5; Retinoblastoma-binding protein RBQ-3Homo sapiens (human)
RuvB-like 1EC 3.6.4.12; 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; 54 kDa erythrocyte cytosolic protein; ECP-54; INO80 complex subunit H; Nuclear matrix protein 238; NMP 238; Pontin 52; TIP49a; TIP60-associated protein 54-alHomo sapiens (human)
Proteasome subunit beta type-11EC 3.4.25.1; Proteasome subunit beta-5tHomo sapiens (human)
26S proteasome non-ATPase regulatory subunit 1126S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit p44.5Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 1226S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55Homo sapiens (human)
MeninHomo sapiens (human)
26S proteasome non-ATPase regulatory subunit 14EC 3.4.19.-; 26S proteasome regulatory subunit RPN11; 26S proteasome-associated PAD1 homolog 1Homo sapiens (human)
Proteasome subunit alpha type-7Proteasome subunit RC6-1; Proteasome subunit XAPC7Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 326S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; Proteasome subunit p58Homo sapiens (human)
26S proteasome regulatory subunit 6A26S proteasome AAA-ATPase subunit RPT5; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; Tat-binding protein 1; TBP-1Homo sapiens (human)
Proteasome subunit alpha type-130 kDa prosomal protein; PROS-30; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome component C2; Proteasome nu chainHomo sapiens (human)
Proteasome subunit alpha type-2Macropain subunit C3; Multicatalytic endopeptidase complex subunit C3; Proteasome component C3Homo sapiens (human)
Proteasome subunit alpha type-3Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8Homo sapiens (human)
Proteasome subunit alpha type-4Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; Proteasome component C9; Proteasome subunit LHomo sapiens (human)
Proteasome subunit alpha type-5Macropain zeta chain; Multicatalytic endopeptidase complex zeta chain; Proteasome zeta chainHomo sapiens (human)
Proteasome subunit beta type-426 kDa prosomal protein; HsBPROS26; PROS-26; Macropain beta chain; Multicatalytic endopeptidase complex beta chain; Proteasome beta chain; Proteasome chain 3; HsN3Homo sapiens (human)
Proteasome subunit beta type-6EC 3.4.25.1; Macropain delta chain; Multicatalytic endopeptidase complex delta chain; Proteasome delta chain; Proteasome subunit YHomo sapiens (human)
26S proteasome regulatory subunit 726S proteasome AAA-ATPase subunit RPT1; Proteasome 26S subunit ATPase 2; Protein MSS1Homo sapiens (human)
Proteasome subunit beta type-10EC 3.4.25.1; Low molecular mass protein 10; Macropain subunit MECl-1; Multicatalytic endopeptidase complex subunit MECl-1; Proteasome MECl-1; Proteasome subunit beta-2iHomo sapiens (human)
26S proteasome regulatory subunit 6B26S proteasome AAA-ATPase subunit RPT3; MB67-interacting protein; MIP224; Proteasome 26S subunit ATPase 4; Tat-binding protein 7; TBP-7Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 826S proteasome regulatory subunit RPN12; 26S proteasome regulatory subunit S14; p31Homo sapiens (human)
Transcription activator BRG1EC 3.6.4.-; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfHomo sapiens (human)
26S proteasome non-ATPase regulatory subunit 726S proteasome regulatory subunit RPN8; 26S proteasome regulatory subunit S12; Mov34 protein homolog; Proteasome subunit p40Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 426S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; Antisecretory factor 1; AF; ASF; Multiubiquitin chain-binding proteinHomo sapiens (human)
26S proteasome complex subunit SEM126S proteasome complex subunit DSS1; Deleted in split hand/split foot protein 1; Split hand/foot deleted protein 1; Split hand/foot malformation type 1 proteinHomo sapiens (human)
Proteasome subunit alpha type-627 kDa prosomal protein; PROS-27; p27K; Macropain iota chain; Multicatalytic endopeptidase complex iota chain; Proteasome iota chainHomo sapiens (human)
26S proteasome regulatory subunit 4P26s4; 26S proteasome AAA-ATPase subunit RPT2; Proteasome 26S subunit ATPase 1Homo sapiens (human)
26S proteasome regulatory subunit 826S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; Thyroid hormone receptor-interacting protein 1; TRIP1; p45/SUGHomo sapiens (human)
26S proteasome regulatory subunit 10B26S proteasome AAA-ATPase subunit RPT4; Proteasome 26S subunit ATPase 6; Proteasome subunit p42Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 226S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; Protein 55.11; Tumor necrosis factor type 1 receptor-associated protein 2Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 626S proteasome regulatory subunit RPN7; 26S proteasome regulatory subunit S10; Breast cancer-associated protein SGA-113M; Phosphonoformate immuno-associated protein 4; Proteasome regulatory particle subunit p44S10; p42AHomo sapiens (human)
Ubiquitin carboxyl-terminal hydrolase 34EC 3.4.19.12; Deubiquitinating enzyme 34; Ubiquitin thioesterase 34; Ubiquitin-specific-processing protease 34Homo sapiens (human)
Proteasome subunit alpha-type 8Proteasome alpha 4 subunit; Alpha4s; Proteasome subunit alpha-type 7-likeHomo sapiens (human)
Proteasome subunit beta type-7EC 3.4.25.1; Macropain chain Z; Multicatalytic endopeptidase complex chain Z; Proteasome subunit ZHomo sapiens (human)
26S proteasome non-ATPase regulatory subunit 126S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112Homo sapiens (human)
Set1/Ash2 histone methyltransferase complex subunit ASH2ASH2-like proteinHomo sapiens (human)
26S proteasome non-ATPase regulatory subunit 1326S proteasome regulatory subunit RPN9; 26S proteasome regulatory subunit S11; 26S proteasome regulatory subunit p40.5Homo sapiens (human)
14-3-3 protein zeta/deltaProtein kinase C inhibitor protein 1; KCIP-1Homo sapiens (human)
Proteasome activator complex subunit 111S regulator complex subunit alpha; REG-alpha; Activator of multicatalytic protease subunit 1; Interferon gamma up-regulated I-5111 protein; IGUP I-5111; Proteasome activator 28 subunit alpha; PA28a; PA28alphaHomo sapiens (human)
Cullin-3CUL-3Homo sapiens (human)
Proteasome activator complex subunit 211S regulator complex subunit beta; REG-beta; Activator of multicatalytic protease subunit 2; Proteasome activator 28 subunit beta; PA28b; PA28betaHomo sapiens (human)
APC membrane recruitment protein 1Amer1; Protein FAM123B; Wilms tumor gene on the X chromosome proteinHomo sapiens (human)
26S proteasome non-ATPase regulatory subunit 926S proteasome regulatory subunit p27Homo sapiens (human)
Transducin-like enhancer protein 2Enhancer of split groucho-like protein 2; ESG2Homo sapiens (human)
Transducin-like enhancer protein 3Enhancer of split groucho-like protein 3; ESG3Homo sapiens (human)
Transducin-like enhancer protein 4Grg-4; Groucho-related protein 4Homo sapiens (human)
Transducin-like enhancer protein 1E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1Homo sapiens (human)
Tyrosine-protein kinase RYKEC 2.7.10.1Homo sapiens (human)
Runt-related transcription factor 3Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3; CBF-alpha-3; Oncogene AML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEA2-alpha C; PEBP2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor Homo sapiens (human)
Proteasome activator complex subunit 4Proteasome activator PA200Homo sapiens (human)
26S proteasome non-ATPase regulatory subunit 526S protease subunit S5 basic; 26S proteasome subunit S5BHomo sapiens (human)
Histone H3.1tH3/t; H3t; H3/g; Histone H3.4Homo sapiens (human)
Kelch-like protein 12CUL3-interacting protein 1; DKIR homolog; hDKIRHomo sapiens (human)
ParafibrominCell division cycle protein 73 homolog; Hyperparathyroidism 2 proteinHomo sapiens (human)
E3 ubiquitin-protein ligase HECW1EC 2.3.2.26; HECT, C2 and WW domain-containing protein 1; HECT-type E3 ubiquitin transferase HECW1; NEDD4-like E3 ubiquitin-protein ligase 1; hNEDL1Homo sapiens (human)
RNA polymerase-associated protein LEO1Replicative senescence down-regulated leo1-like proteinHomo sapiens (human)
Proteasome inhibitor PI31 subunithPI31Homo sapiens (human)
Chromodomain-helicase-DNA-binding protein 8CHD-8; EC 3.6.4.12; ATP-dependent helicase CHD8; Helicase with SNF2 domain 1Homo sapiens (human)
E3 ubiquitin-protein ligase RNF146EC 2.3.2.27; Dactylidin; Iduna; RING finger protein 146; RING-type E3 ubiquitin transferase RNF146Homo sapiens (human)
Dapper homolog 1hDPR1; Dapper antagonist of catenin 1; Hepatocellular carcinoma novel gene 3 proteinHomo sapiens (human)
Protein DapleCoiled-coil domain-containing protein 88C; Dvl-associating protein with a high frequency of leucine residues; hDaple; Hook-related protein 2; HkRP2Homo sapiens (human)
F-box/WD repeat-containing protein 1AE3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; pIkappaBalpha-E3 receptor subunitHomo sapiens (human)
Protein chibby homolog 1ARPP-binding protein; Cytosolic leucine-rich protein; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1Homo sapiens (human)
Transformation/transcription domain-associated protein350/400 kDa PCAF-associated factor; PAF350/400; STAF40; Tra1 homologHomo sapiens (human)
Wnt inhibitory factor 1WIF-1Homo sapiens (human)

Compounds (8)

CompoundDescription
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.