Pathways > T cell receptor signaling (PLC gamma, PKC, Ras and ERK cascade) ( CD4 T cell receptor signaling (ERK cascade) )

Page last updated: 2024-10-06

T cell receptor signaling (PLC gamma, PKC, Ras and ERK cascade) ( CD4 T cell receptor signaling (ERK cascade) )

Proteins (21)

Protein	Synonyms	Taxonomy
Tyrosine-protein kinase ZAP-70	EC 2.7.10.2; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase	Mus musculus (house mouse)
T cell receptor alpha chain constant		Homo sapiens (human)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	EC 3.1.4.11; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2	Rattus norvegicus (Norway rat)
Inositol 1,4,5-trisphosphate receptor type 3	IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor	Rattus norvegicus (Norway rat)
RAS guanyl-releasing protein 1	Calcium and DAG-regulated guanine nucleotide exchange factor II; CalDAG-GEFII; Ras guanyl-releasing protein	Rattus norvegicus (Norway rat)
Linker for activation of T-cells family member 1	36 kDa phospho-tyrosine adapter protein; pp36; p36-38	Rattus norvegicus (Norway rat)
T-cell surface glycoprotein CD3 delta chain	T-cell receptor T3 delta chain	Rattus norvegicus (Norway rat)
Proto-oncogene tyrosine-protein kinase LCK	EC 2.7.10.2; Lymphocyte cell-specific protein-tyrosine kinase; p56-LCK	Rattus norvegicus (Norway rat)
Tyrosine-protein kinase ITK/TSK	EC 2.7.10.2; IL-2-inducible T-cell kinase; Kinase EMT; Kinase TLK; T-cell-specific kinase	Mus musculus (house mouse)
GTPase NRas	EC 3.6.5.2; Transforming protein N-Ras	Xenopus laevis (African clawed frog)
T-cell receptor beta-1 chain C region		Mus musculus (house mouse)
H-2 class II histocompatibility antigen, E-K alpha chain		Mus musculus (house mouse)
T-cell surface glycoprotein CD4	T-cell surface antigen T4/Leu-3; W3/25 antigen	Rattus norvegicus (Norway rat)
T-cell surface glycoprotein CD3 epsilon chain	T-cell surface antigen T3/Leu-4 epsilon chain	Mus musculus (house mouse)
T-cell surface glycoprotein CD3 zeta chain	T-cell receptor T3 zeta chain	Mus musculus (house mouse)
Mitogen-activated protein kinase ERK-A	EC 2.7.11.24; Extracellular-regulated kinase A; Protein rolled	Drosophila melanogaster (fruit fly)
Raf homolog serine/threonine-protein kinase	EC 2.7.11.1; Abnormal cell lineage protein 45	Caenorhabditis elegans
Dual specificity mitogen-activated protein kinase kinase mek-2	MAP kinase kinase mek-2; EC 2.7.12.2	Caenorhabditis elegans
T-cell surface glycoprotein CD3 gamma chain	T-cell receptor T3 gamma chain	Rattus norvegicus (Norway rat)
Son of sevenless homolog	Guanine nucleotide exchange factor for RAS	Caenorhabditis elegans
Growth factor receptor-bound protein 2-B	Adapter protein GRB2-B; SH2/SH3 adapter GRB2-B	Xenopus laevis (African clawed frog)

Compounds (4)

Compound	Description
Calcium	A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
guanosine diphosphate	A guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
guanosine triphosphate	Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.
inositol 1,4,5-trisphosphate	Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.