| Protein | Synonyms | Taxonomy |
|---|
| RAF proto-oncogene serine/threonine-protein kinase | EC 2.7.11.1; Proto-oncogene c-RAF; cRaf; Raf-1 | Homo sapiens (human) |
| Protein kinase C beta type | PKC-B; PKC-beta; EC 2.7.11.13 | Homo sapiens (human) |
| Tyrosine-protein kinase Lck | EC 2.7.10.2; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK | Homo sapiens (human) |
| Tyrosine-protein kinase Fyn | EC 2.7.10.2; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn | Homo sapiens (human) |
| Protein kinase C alpha type | PKC-A; PKC-alpha; EC 2.7.11.13 | Homo sapiens (human) |
| NF-kappa-B inhibitor alpha | I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3 | Homo sapiens (human) |
| Mitogen-activated protein kinase 3 | MAP kinase 3; MAPK 3; EC 2.7.11.24; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p44-ERK1 | Homo sapiens (human) |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-k | Homo sapiens (human) |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; EC 2.7.1.137; EC 2.7.1.153; EC 2.7.1.154; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; PtdIns-3-kinase subunit p110-gamma; p110gamma; Phosph | Homo sapiens (human) |
| Dual specificity mitogen-activated protein kinase kinase 1 | MAP kinase kinase 1; MAPKK 1; MKK1; EC 2.7.12.2; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1 | Homo sapiens (human) |
| Transcription factor p65 | Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 | Homo sapiens (human) |
| Mitogen-activated protein kinase kinase kinase 1 | EC 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1 | Homo sapiens (human) |
| T cell receptor alpha chain constant | | Homo sapiens (human) |
| Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform | EC 3.1.3.16; CAM-PRP catalytic subunit; Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform | Homo sapiens (human) |
| Polyubiquitin-C | | Homo sapiens (human) |
| Nuclear factor of activated T-cells, cytoplasmic 1 | NF-ATc1; NFATc1; NFAT transcription complex cytosolic component; NF-ATc; NFATc | Homo sapiens (human) |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | EC 3.1.4.11; PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1 | Homo sapiens (human) |
| Transcription factor AP-1 | Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 | Homo sapiens (human) |
| Phosphatidylinositol 3-kinase regulatory subunit alpha | PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha | Homo sapiens (human) |
| SHC-transforming protein 1 | SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1 | Homo sapiens (human) |
| Tyrosine-protein kinase ZAP-70 | EC 2.7.10.2; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase | Homo sapiens (human) |
| Mitogen-activated protein kinase 8 | MAP kinase 8; MAPK 8; EC 2.7.11.24; JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1 | Homo sapiens (human) |
| Growth factor receptor-bound protein 2 | Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2 | Homo sapiens (human) |
| Calmodulin-2 | | Homo sapiens (human) |
| Linker for activation of T-cells family member 1 | 36 kDa phospho-tyrosine adapter protein; pp36; p36-38 | Homo sapiens (human) |
| Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | EC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit beta isoform; CNA beta | Homo sapiens (human) |
| Nuclear factor NF-kappa-B p105 subunit | DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Homo sapiens (human) |
| Tyrosine-protein phosphatase non-receptor type 7 | EC 3.1.3.48; Hematopoietic protein-tyrosine phosphatase; HEPTP; Protein-tyrosine phosphatase LC-PTP | Homo sapiens (human) |
| Ras-related C3 botulinum toxin substrate 1 | EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1 | Homo sapiens (human) |
| Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | EC 3.1.3.16; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform | Homo sapiens (human) |
| Son of sevenless homolog 1 | SOS-1 | Homo sapiens (human) |
| Nuclear factor of activated T-cells, cytoplasmic 2 | NF-ATc2; NFATc2; NFAT pre-existing subunit; NF-ATp; T-cell transcription factor NFAT1 | Homo sapiens (human) |
| GTPase HRas | EC 3.6.5.2; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras | Homo sapiens (human) |
| Calmodulin-1 | | Homo sapiens (human) |
| Dual specificity mitogen-activated protein kinase kinase 4 | MAP kinase kinase 4; MAPKK 4; EC 2.7.12.2; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK | Homo sapiens (human) |
| RAS guanyl-releasing protein 1 | Calcium and DAG-regulated guanine nucleotide exchange factor II; CalDAG-GEFII; Ras guanyl-releasing protein | Homo sapiens (human) |
| Proto-oncogene vav | | Homo sapiens (human) |
| Nuclear factor of activated T-cells, cytoplasmic 3 | NF-ATc3; NFATc3; NFATx; T-cell transcription factor NFAT4; NF-AT4; NF-AT4c | Homo sapiens (human) |
| Nuclear factor of activated T-cells, cytoplasmic 4 | NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3 | Homo sapiens (human) |
| Proto-oncogene c-Fos | Cellular oncogene fos; G0/G1 switch regulatory protein 7 | Homo sapiens (human) |
| ETS domain-containing protein Elk-1 | | Homo sapiens (human) |
| T-cell surface glycoprotein CD3 delta chain | T-cell receptor T3 delta chain | Homo sapiens (human) |
| T cell receptor beta constant 1 | | Homo sapiens (human) |
| T-cell surface glycoprotein CD3 epsilon chain | T-cell surface antigen T3/Leu-4 epsilon chain | Homo sapiens (human) |
| T-cell surface glycoprotein CD3 gamma chain | T-cell receptor T3 gamma chain | Homo sapiens (human) |
| Calmodulin-3 | | Homo sapiens (human) |
| T-cell surface glycoprotein CD3 zeta chain | T-cell receptor T3 zeta chain | Homo sapiens (human) |
| Compound | Description |
|---|
| Orthophosphate | |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| tacrolimus | A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| inositol 1,4,5-trisphosphate | Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. |
| Phosphatidylinositol 4,5-Diphosphate | A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994) |