Page last updated: 2024-10-06

Synthesis of substrates in N-glycan biosythesis

Proteins (37)

ProteinSynonymsTaxonomy
Lysosomal protective proteinEC 3.4.16.5; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; Protective protein cathepsin A; PPCA; Protective protein for beta-galactosidaseHomo sapiens (human)
Beta-galactosidaseEC 3.2.1.23; Acid beta-galactosidase; Lactase; Elastin receptor 1Homo sapiens (human)
N-acylneuraminate-9-phosphataseEC 3.1.3.29; Haloacid dehalogenase-like hydrolase domain-containing protein 4; Neu5Ac-9-PaseHomo sapiens (human)
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseUDP-GlcNAc-2-epimerase/ManAc kinaseHomo sapiens (human)
Mannose-6-phosphate isomeraseEC 5.3.1.8; Phosphohexomutase; Phosphomannose isomerase; PMIHomo sapiens (human)
Sialidase-4EC 3.2.1.18; N-acetyl-alpha-neuraminidase 4Homo sapiens (human)
Sialidase-3EC 3.2.1.18; Ganglioside sialidasedis; Membrane sialidase; N-acetyl-alpha-neuraminidase 3Homo sapiens (human)
Sialidase-2EC 3.2.1.18; Cytosolic sialidase; N-acetyl-alpha-neuraminidase 2Homo sapiens (human)
SialinH(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular H(+)/Aspartate-glutamate cotransporterHomo sapiens (human)
Dehydrodolichyl diphosphate synthase complex subunit NUS1EC 2.5.1.87; Cis-prenyltransferase subunit NgBR; Nogo-B receptor; NgBR; Nuclear undecaprenyl pyrophosphate synthase 1 homologHomo sapiens (human)
Sialidase-1EC 3.2.1.18; Acetylneuraminyl hydrolase; G9 sialidase; Lysosomal sialidase; N-acetyl-alpha-neuraminidase 1Homo sapiens (human)
Diphosphomevalonate decarboxylaseEC 4.1.1.33; Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylaseHomo sapiens (human)
Polyprenol reductaseEC 1.3.1.94; 3-oxo-5-alpha-steroid 4-dehydrogenase 3; 1.3.1.22; Steroid 5-alpha-reductase 2-like; Steroid 5-alpha-reductase 3; S5AR 3; SR type 3Homo sapiens (human)
Dehydrodolichyl diphosphate synthase complex subunit DHDDSEC 2.5.1.87; Cis-isoprenyltransferase; CIT; Cis-IPTase; Cis-prenyltransferase subunit hCIT; Epididymis tissue protein Li 189mHomo sapiens (human)
N-acylneuraminate cytidylyltransferaseEC 2.7.7.43; CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthaseHomo sapiens (human)
N-acetylglucosamine-6-phosphate deacetylaseGlcNAc 6-P deacetylase; EC 3.5.1.25; Amidohydrolase domain-containing protein 2Homo sapiens (human)
GDP-mannose 4,6 dehydrataseEC 4.2.1.47; GDP-D-mannose dehydratase; GMDHomo sapiens (human)
Uridine diphosphate glucose pyrophosphatase NUDT14UDPG pyrophosphatase; UGPPase; EC 3.6.1.45; Nucleoside diphosphate-linked moiety X motif 14; Nudix motif 14Homo sapiens (human)
N-acetyl-D-glucosamine kinaseN-acetylglucosamine kinase; EC 2.7.1.59; GlcNAc kinaseHomo sapiens (human)
Dolichol kinaseEC 2.7.1.108; Transmembrane protein 15Homo sapiens (human)
Glucosamine 6-phosphate N-acetyltransferaseEC 2.3.1.4; Phosphoglucosamine acetylase; Phosphoglucosamine transacetylaseHomo sapiens (human)
Fucose-1-phosphate guanylyltransferaseEC 2.7.7.30; GDP-L-fucose diphosphorylase; GDP-L-fucose pyrophosphorylaseHomo sapiens (human)
N-acetylneuraminate lyaseNALase; EC 4.1.3.3; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialate-pyruvate lyase; Sialic acid aldolase; Sialic acid lyaseHomo sapiens (human)
Dolichyldiphosphatase 1EC 3.6.1.43; Dolichyl pyrophosphate phosphatase 1Homo sapiens (human)
L-fucose kinaseFucokinase; EC 2.7.1.52Homo sapiens (human)
N-acylglucosamine 2-epimeraseAGE; EC 5.1.3.8; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; Renin-binding protein; RnBPHomo sapiens (human)
GDP-L-fucose synthaseEC 1.1.1.271; GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; Protein FX; Red cell NADP(H)-binding protein; Short-chain dehydrogenase/reductase family 4E member 1Homo sapiens (human)
Phosphoacetylglucosamine mutasePAGM; EC 5.4.2.3; Acetylglucosamine phosphomutase; N-acetylglucosamine-phosphate mutase; Phosphoglucomutase-3; PGM 3Homo sapiens (human)
Fucose mutarotaseEC 5.1.3.29Homo sapiens (human)
Dolichol-phosphate mannosyltransferase subunit 1EC 2.4.1.83; Dolichol-phosphate mannose synthase subunit 1; DPM synthase subunit 1; Dolichyl-phosphate beta-D-mannosyltransferase subunit 1; Mannose-P-dolichol synthase subunit 1; MPD synthase subunit 1Homo sapiens (human)
Dolichol phosphate-mannose biosynthesis regulatory proteinDolichol-phosphate mannose synthase subunit 2; DPM synthase subunit 2Homo sapiens (human)
CMP-sialic acid transporterCMP-SA-Tr; CMP-Sia-Tr; Solute carrier family 35 member A1Homo sapiens (human)
UDP-N-acetylhexosamine pyrophosphorylaseAntigen X; AGX; Sperm-associated antigen 2Homo sapiens (human)
GDP-fucose transporter 1Solute carrier family 35 member C1Homo sapiens (human)
Sialic acid synthaseN-acetylneuraminate synthase; 2.5.1.56; N-acetylneuraminate-9-phosphate synthase; 2.5.1.57; N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthaseHomo sapiens (human)
Dolichol-phosphate mannosyltransferase subunit 3Dolichol-phosphate mannose synthase subunit 3; DPM synthase subunit 3; Dolichyl-phosphate beta-D-mannosyltransferase subunit 3; Mannose-P-dolichol synthase subunit 3; MPD synthase subunit 3; Prostin-1Homo sapiens (human)
Dolichyl-phosphate beta-glucosyltransferaseDolP-glucosyltransferase; EC 2.4.1.117; Asparagine-linked glycosylation protein 5 homologHomo sapiens (human)

Compounds (33)

CompoundDescription
hydronium ion
uridine diphosphateA uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Orthophosphate
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
Uridine TriphosphateUridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
gdp-4-keto-6-deoxymannose
Guanosine MonophosphateA guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.
Guanosine DiphosphateA guanine nucleotide containing two phosphate groups esterified to the sugar moiety.
cytarabineA pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Pyruvic AcidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
isopentenyl pyrophosphatesubstrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
N-acetylmannosamine 6-phosphate
glucosamine 6-phosphateRN given refers to parent cpd
5-diphosphomevalonic acidRN given refers to ion(1-)
farnesyl pyrophosphatea sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
polyglutamineRN given for (D)-isomer
Cytidine MonophosphateCytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
Cytidine TriphosphateCytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.
Uridine Monophosphate5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
Cytidine DiphosphateCytidine 5'-(trihydrogen diphosphate). A cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. Synonyms: CRPP; cytidine pyrophosphate.
dolichol pyrophosphate
Coenzyme A
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
dolichol monophosphate
N-acetylmannosamineRN given refers to cpd without isomeric designation
fucopyranosyl phosphatestructure given in first source; RN given for (beta-L)-isomer